Syndromes that Mimic an Excess of Mineralocorticoids
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- 作者：Chiara Sabbadin ; Decio Armanini
- 关键词：Pseudohyperaldosteronism ; Aldosterone ; Mineralocorticoid receptor ; Hypertension ; 11 Hydroxysteroid dehydrogenase type 2 ; Apparent mineralocorticoid excess syndrome ; Deoxycorticosterone ; Licorice
- 刊名：High Blood Pressure & Cardiovascular Prevention
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：23
- 期：3
- 页码：231-235
- 全文大小：562 KB
- 刊物主题：Cardiology; Pharmacotherapy;
- 出版者：Springer International Publishing
- ISSN：1179-1985
- 卷排序：23
文摘
Pseudohyperaldosteronism is characterized by a clinical picture of hyperaldosteronism with suppression of renin and aldosterone. It can be due to endogenous or exogenous substances that mimic the effector mechanisms of aldosterone, leading not only to alterations of electrolytes and hypertension, but also to an increased inflammatory reaction in several tissues. Enzymatic defects of adrenal steroidogenesis (deficiency of 17α-hydroxylase and 11β-hydroxylase), mutations of mineralocorticoid receptor (MR) and alterations of expression or saturation of 11-hydroxysteroid dehydrogenase type 2 (apparent mineralocorticoid excess syndrome, Cushing’s syndrome, excessive intake of licorice, grapefruits or carbenoxolone) are the main causes of pseudohyperaldosteronism. In these cases treatment with dexamethasone and/or MR-blockers is useful not only to normalize blood pressure and electrolytes, but also to prevent the deleterious effects of prolonged over-activation of MR in epithelial and non-epithelial tissues. Genetic alterations of the sodium channel (Liddle’s syndrome) or of the sodium-chloride co-transporter (Gordon’s syndrome) cause abnormal sodium and water reabsorption in the distal renal tubules and hypertension. Treatment with amiloride and thiazide diuretics can respectively reverse the clinical picture and the renin aldosterone system. Finally, many other more common situations can lead to an acquired pseudohyperaldosteronism, like the expansion of volume due to exaggerated water and/or sodium intake, and the use of drugs, as contraceptives, corticosteroids, β-adrenergic agonists and FANS. In conclusion, syndromes or situations that mimic aldosterone excess are not rare and an accurate personal and pharmacological history is mandatory for a correct diagnosis and avoiding unnecessary tests and mistreatments.