Simultaneous determination of 5-hydroxytryptamine and dopamine using ionic liquid functionalized graphene

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• 作者：Panpan Liu ; Mingjun Dong ; Juanjuan Lu ; Huixia Guo ; Xiaoquan Lu ; Xiuhui Liu
• 关键词：Functionalized graphene ; Amine ; terminated ionic liquid ; 5 ; Hydroxytryptamine ; Dopamine ; Electrochemical biosensor
• 刊名：Ionics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：21
• 期：4
• 页码：1111-1119
• 全文大小：1,353 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Electrochemistry
  Materials Science
  Physical Chemistry
  Condensed Matter
  Renewable Energy Sources
  Electrical Power Generation and Transmission
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1862-0760

文摘

An electrochemical sensor for simultaneous determination of 5-hydroxytryptamine (5-HT) and dopamine (DA) was developed in this paper based on an ionic liquid functionalized-graphene (IL-graphene) modified glassy carbon electrode. Transmission electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to characterize the formation of the IL-graphene composites. Due to functionalization of the ionic liquid, IL-graphene can not only be dispersed well in aqueous solutions, but also exhibit a strong positive charge. Cyclic voltammetry and differential pulse voltammetry results demonstrated that 5-HT and DA can be detected selectively and sensitively at the constructed electrode with peak-to-peak separation about 164?mV. Under the optimized condition, the linear responses were obtained in the range of 2.0?×-0? to 1.0?×-0??M with a detection limit of 6.7?×-0??M for 5-HT, and in the range of 1.0?×-0? to 1.0?×-0??M with a detection limit of 3.3?×-0??M for DA (S/N--), respectively. Moreover, the designed sensor was further applied to the simultaneous determination 5-HT and DA levels in human serum samples with reliable recovery. The excellent performance of this sensor was ascribed to the network-like structure of IL-graphene which provided large surface area to contact 5-HT or DA.