Hypertension risk in idiopathic hyperCKemia

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• 作者：L. M. Brewster ; S. van Bree ; J. C. Reijneveld ; N. C. Notermans ; W. M. M. Verschuren ; J. F. Clark ; G. A. van Montfrans and M. de Visser
• 关键词：idiopathic hyperCKemia ; creatine kinase ; blood pressure ; hypertension
• 刊名：Journal of Neurology
• 出版年：2008
• 出版时间：January, 2008
• 年：2008
• 卷：255
• 期：1
• 页码：11-15
• 全文大小：273.9 KB

文摘

Patients with idiopathic hyperCKemia are usually reassured and discharged. However, these subjects may have increased hypertension risk, based on data from our population study, which showed that the population tertile with the highest serum creatine kinase activities had the highest systolic and diastolic blood pressure levels. Therefore, we assessed whether subjects with idiopathic hyperCKemia have greater occurrence of hypertension than controls. We included 46 participants aged 18 to 67 years, diagnosed with idiopathic hyperCKemia at the departments of Neurology of the Universities of Amsterdam and Utrecht, The Netherlands. We found that 48 % of the subjects with idiopathic hyperCKemia were hypertensive, as compared to 19 % of the random population controls (n = 22,612, aged 20 to 65 years), an odds ratio of 3.9 (95 % CI, 2.2 to 6.9) before, and 2.0 (1.1 to 3.8) after adjustment for sex, age, and body mass index.