Severe hyperlactatemia, lactate clearance and mortality in unselected critically ill patients

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• 作者：Sebastian A. Haas ; Theresa Lange ; Bernd Saugel ; Martin Petzoldt…
• 关键词：Hyperlactatemia ; Circulatory shock ; Sepsis ; Critical care ; Lactate ; Intensive care unit
• 刊名：Intensive Care Medicine
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：42
• 期：2
• 页码：202-210
• 全文大小：605 KB
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• 作者单位：Sebastian A. Haas (1)
  Theresa Lange (2)
  Bernd Saugel (1)
  Martin Petzoldt (1)
  Valentin Fuhrmann (2)
  Maria Metschke (2)
  Stefan Kluge (2)
  
  1. Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
  2. Department of Intensive Care Medicine, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
  
• 刊物主题：Intensive / Critical Care Medicine; Anesthesiology; Emergency Medicine; Pneumology/Respiratory System; Pain Medicine; Pediatrics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1238

文摘

Purpose Hyperlactatemia may occur for a variety of reasons and is a predictor of poor clinical outcome. However, only limited data are available on the underlying causes of hyperlactatemia and the mortality rates associated with severe hyperlactatemia in critically ill patients. We therefore aimed to evaluate the etiology of severe hyperlactatemia (defined as a lactate level >10 mmol/L) in a large cohort of unselected ICU patients. We also aimed to evaluate the association between severe hyperlactatemia and lactate clearance with ICU mortality.