Hyperuricemia, Hypertension, and Chronic Kidney Disease: an Emerging Association

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• 作者：Samir G. Mallat ; Sahar Al Kattar ; Bassem Y. Tanios…
• 关键词：Uric acid ; Hyperuricemia ; Hypertension ; Chronic kidney disease
• 刊名：Current Hypertension Reports
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：18
• 期：10
• 全文大小：1,209 KB
• 刊物主题：Internal Medicine; Cardiology; Metabolic Diseases; Nephrology; Primary Care Medicine; General Practice / Family Medicine;
• 出版者：Springer US
• ISSN：1534-3111
• 卷排序：18

文摘

Uric acid is a product of purine metabolism and has been linked to gout and kidney calculi. Chronic kidney disease (CKD) and hypertension (HTN) are two major public health problems, and both are associated with increased risk of cardiovascular events. Emerging evidence suggests a pathogenic role of hyperuricemia in the development of HTN and CKD, in addition to progression of CKD, by inducing renal inflammation, endothelial dysfunction, and activation of the renin-angiotensin system. In addition, several epidemiological studies have linked hyperuricemia with an increased risk of HTN and CKD. A few clinical trials have assessed the use of uric acid-lowering therapies such as allopurinol and febuxostat in the management of HTN and delaying progression of CKD. To date, most of these trials are short-term with a small sample size; however, their results are encouraging and provide a rationale for larger randomized controlled trials to establish the role of uric acid-lowering therapies in the management of HTN, in addition to prevention of CKD progression and cardiovascular events.