Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity
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- 作者：Livia B. Pascoal ; Bruna Bombassaro ; Albina F. Ramalho…
- 关键词：Hypothalamus ; Nutrient ; Metabolism ; Brain ; Lipid
- 刊名：Journal of Neuroinflammation
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：1414KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
- 卷排序：14
文摘
BackgroundDiet-induced hypothalamic inflammation is an important mechanism leading to dysfunction of neurons involved in controlling body mass. Studies have shown that polyunsaturated fats can reduce hypothalamic inflammation. Here, we evaluated the presence and function of RvD2, a resolvin produced from docosahexaenoic acid, in the hypothalamus of mice.