Gender-specific effects of CGP 55845, GABAB receptor antagonist, on neuromuscular coordination, learning and memory formation in albino mouse following neonatal hypoxia–ischemia insult

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• 作者：Quratul Ane Gillani ; Atif Akbar ; Muhammad Ali ; Furhan Iqbal
• 关键词：CGP 55845 ; Hypoxia ischemia insult ; Albino mice ; Morris water maze ; Brain infract
• 刊名：Neurological Sciences
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：36
• 期：6
• 页码：961-969
• 全文大小：1,254 KB
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• 作者单位：Quratul Ane Gillani (1) (3)
  Atif Akbar (2) (3)
  Muhammad Ali (2) (3)
  Furhan Iqbal (1) (3)
  
  1. Zoology Division, Department of Zoology, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, 60800, Pakistan
  3. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, 60800, Pakistan
  2. Department of Statistics, Bahauddin Zakariya University, Multan, 60800, Pakistan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478

文摘

GABA_B receptor antagonists are experimentally proved as spatial memory enhancers in mouse models but their role has not been described following hypoxic–ischemic insult. 10-day-old albino mice were subjected to Murine model of hypoxia and ischemia. Following brain damage, mice were fed on normal rodent diet till they were 13?weeks old. At this time point, mice were divided into two groups. Group 1 received saline and group 2 received intraperitoneally CGP 55845 (1?mg/ml solvent/Kg body weight) for 12?days. Behavioural observations were made during rota rod, open field and Morris water maze test along with brain infarct measurement?in both CGP 55845 treated and untreated groups. It was observed that application of GABA_B receptor antagonist improved the over all?motor function in male and female albino mice but effects were more pronounced in males. In open field, CGP 55845-treated female mice showed poor performance. CGP 55845 had no significant effect on learning and memory formation during Morris water maze test and also on brain infract size in both genders following hypoxia ischemia encephalopathy. Effects of?CGP 55845 can be further explored in a dose and duration dependent manner?to improve the learning and memory in albino mice following neonatal brain damage.