Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

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• 作者：Do Hyun Jung ; Sang Yong Son ; Aung Myint Oo ; Young Suk Park…
• 关键词：Hyperthermia ; Pneumoperitoneum ; Aerosol ; Peritoneum therapy ; Laparoscopic surgery ; Peritoneal carcinomatosis
• 刊名：Surgical Endoscopy
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：30
• 期：10
• 页码：4258-4264
• 全文大小：976 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Gynecology
  Gastroenterology
  Hepatology
  Proctology
  Abdominal Surgery
  
• 出版者：Springer New York
• ISSN：1432-2218
• 卷排序：30

文摘

BackgroundPeritoneal carcinomatosis is an unmet therapeutic need. Several types of intraperitoneal chemotherapy have been introduced. However, hyperthermic intraperitoneal chemotherapy has limited drug distribution and poor peritoneal penetration. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) does not have the benefits of hyperthermia. We developed a device to apply hyperthermic PIPAC (H-PAC) and evaluated its feasibility in a porcine model.