Surface modification of silk fibroin nanofibrous mat with dextran for wound dressing

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• 作者：Moo Kon Kim (1)
  Hyo Won Kwak (1)
  Hyung Hwan Kim (1)
  Tae Rin Kwon (2)
  So Young Kim (2)
  Beom Joon Kim (3)
  Young Hwan Park (1)
  Ki Hoon Lee (1) (4) (5)
  
• 关键词：Silk fibroin ; Dextran ; Wound healing ; Wound dressing ; Surface modification
• 刊名：Fibers and Polymers
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：15
• 期：6
• 页码：1137-1145
• 全文大小：1,245 KB
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• 作者单位：Moo Kon Kim (1)
  Hyo Won Kwak (1)
  Hyung Hwan Kim (1)
  Tae Rin Kwon (2)
  So Young Kim (2)
  Beom Joon Kim (3)
  Young Hwan Park (1)
  Ki Hoon Lee (1) (4) (5)
  
  1. Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-921, Korea
  2. Major in Biomedical Science, Department of Medicine, Graduate school, Chung-Ang University, Seoul, 156-755, Korea
  3. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, 156-755, Korea
  4. Center for Food and Bioconvergence, Seoul National University, Seoul, 151-921, Korea
  5. Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Korea
  
• ISSN：1875-0052

文摘

In this study, we examined the effects of a dextran-modified silk fibroin nanofibrous mat (D-SFNM) on wound healing. To increase the hydrophilicity of silk fibroin (SF), the SF nanofibrous mat (SFNM) was modified with oxidized dextran. The D-SFNM absorbed water faster than the SFNM, and the swelling ratio was increased by approximately 80 % compared with the SFNM. An in vitro cell (NIH3T3) test revealed that fewer cells attached to the D-SFNM than the SFNM, but the proliferation of cells was not significantly affected by the presence of dextran. An in vivo wound healing test with mice indicated that the D-SFNM resulted in a good wound recovery effect similar to a commercial wound dressing material. The increased hydrophilicity of the D-SFNM might balance the moist environment at the wound site, which improves the wound healing compared with the SFNM.