Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis
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  • 作者:Sun Young Choi ; Chang Taek OH ; Tae-Rin Kwon ; Hyun Jung Kwon…
  • 关键词:Gain ; switched 311 ; nm Ti ; Sapphire laser ; Atopic dermatitis
  • 刊名:Lasers in Medical Science
  • 出版年:2016
  • 出版时间:September 2016
  • 年:2016
  • 卷:31
  • 期:7
  • 页码:1437-1445
  • 全文大小:2,481 KB
  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Medicine/Public Health, general
    Dentistry
    Laser Technology and Physics and Photonics
    Quantum Optics, Quantum Electronics and Nonlinear Optics
    Applied Optics, Optoelectronics and Optical Devices
  • 出版者:Springer London
  • ISSN:1435-604X
  • 卷排序:31
文摘
Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) was induced in mice by exposure to Dermatophagoides farina. These, NC/Nga mice were then treated with conventional 311-nm NBUVB or the newly developed gain-switched 311-nm Ti:Sapphire laser. The clinical features, dermatitis severity scores, and scratching behavior were assessed. In addition, serologic analyses including inflammatory cytokines and histological analyses were performed. Gain-switched 311-nm Ti:Sapphire laser improved the AD-like skin lesions, severity, and symptoms of AD in the NC/Nga mouse model. This new laser also modulated the immune response found in the AD model, including hyper-IgE, upregulated Th2 cytokines, and the Th2-mediated allergic inflammatory reaction. Gain-switched 311-nm Ti:Sapphire laser shows therapeutic promise via an immune-modulation mechanism in an AD mouse model. These data suggest that gain-switched 311-nm Ti:Sapphire laser may be useful as a targeted phototherapy modality for AD.

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