The clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG)
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- 作者：Ozgur Tanriverdi (1)
Esra Kaytan-Saglam (2)
Sukran Ulger (3)
Ibrahim Vedat Bayoglu (4)
Ibrahim Turker (5)
Turkan Ozturk-Topcu (6)
Suna Cokmert (7)
Serdar Turhal (8)
Esin Oktay (9)
Bulent Karabulut (10)
Diclehan Kilic (3)
Yuksel Kucukzeybek (4)
Berna Oksuzoglu (5)
Nezih Meydan (9)
Vildan Kaya (11)
Tulay Akman (12)
Kamuran Ibis (13)
Mert Saynak (13)
Cenk Ahmet Sen (14)
Ozlem Uysal-Sonmez (15)
Kezban Nur Pilanc? (16)
Gokhan Demir (16)
Sezer Saglam (16)
Muharrem Kocar (17)
Serkan Menekse (18)
Gamze Goksel (18)
Burcu Yapar-Taskoylu (19)
Arzu Yaren (19)
Ummugul Uyeturk (20)
Nilufer Avci (21)
Bengu Denizli (22)
Esra Ilis-Temiz (22) - 关键词：Colorectal cancer ; Brain metastasis ; Prognosis
- 刊名：Medical Oncology
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：31
- 期：9
- 全文大小：238 KB
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Esra Kaytan-Saglam (2)
Sukran Ulger (3)
Ibrahim Vedat Bayoglu (4)
Ibrahim Turker (5)
Turkan Ozturk-Topcu (6)
Suna Cokmert (7)
Serdar Turhal (8)
Esin Oktay (9)
Bulent Karabulut (10)
Diclehan Kilic (3)
Yuksel Kucukzeybek (4)
Berna Oksuzoglu (5)
Nezih Meydan (9)
Vildan Kaya (11)
Tulay Akman (12)
Kamuran Ibis (13)
Mert Saynak (13)
Cenk Ahmet Sen (14)
Ozlem Uysal-Sonmez (15)
Kezban Nur Pilanc? (16)
Gokhan Demir (16)
Sezer Saglam (16)
Muharrem Kocar (17)
Serkan Menekse (18)
Gamze Goksel (18)
Burcu Yapar-Taskoylu (19)
Arzu Yaren (19)
Ummugul Uyeturk (20)
Nilufer Avci (21)
Bengu Denizli (22)
Esra Ilis-Temiz (22)
1. Department of Medical Oncology, Faculty of Medicine, Medical School of Sitki Kocman University, Mugla, 48000, Turkey
2. Department of Radiation Oncology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
3. Department of Radiation Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey
4. Clinic of Medical Oncology, Ataturk Training and Research Hospital, Katip Celebi University, Izmir, Turkey
5. Clinic of Medical Oncology, Dr. Abdurrahman Yurtarslan Oncology Training and Research Hospital, Ankara, Turkey
6. Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
7. Medical Oncology Clinic, Kent Hospital, Izmir, Turkey
8. Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey
9. Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, Ayd?n, Turkey
10. Department of Medical Oncology, Faculty of Medicine, Ege University, Izmir, Turkey
11. Department of Radiation Oncology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
12. Clinic of Medical Oncology, Tepecik Training and Research Hospital, Izmir, Turkey
13. Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey
14. Department of Radiation Oncology, Medical Park Hospital, Izmir University, Izmir, Turkey
15. Department of Medical Oncology, Training and Research Hospital, Sakarya University, Sakarya, Turkey
16. Department of Medical Oncology, Faculty of Medicine, Bilim University, Istanbul, Turkey
17. Medical Oncology Clinic, Training and Research Hospital, Sanliurfa, Turkey
18. Department of Medical Oncology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
19. Department of Medical Oncology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
20. Department of Medical Oncology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
21. Medical Oncology Clinic, State Hospital, Bal?kesir, Turkey
22. Radiation Oncology Clinic, Ataturk State Hospital, Ayd?n, Turkey - ISSN：1559-131X
文摘
Brain metastasis in colorectal cancer is highly rare. In the present study, we aimed to determine the frequency of brain metastasis in colorectal cancer patients and to establish prognostic characteristics of colorectal cancer patients with brain metastasis. In this cross-sectional study, the medical files of colorectal cancer patients with brain metastases who were definitely diagnosed by histopathologically were retrospectively reviewed. Brain metastasis was detected in 2.7?% (n?=?133) of 4,864 colorectal cancer patients. The majority of cases were male (53?%), older than 65?years (59?%), with rectum cancer (56?%), a poorly differentiated tumor (70?%); had adenocarcinoma histology (97?%), and metachronous metastasis (86?%); received chemotherapy at least once for metastatic disease before brain metastasis developed (72?%), had progression with lung metastasis before (51?%), and 26?% (n?=?31) of patients with extracranial disease at time the diagnosis of brain metastasis had both lung and bone metastases. The mean follow-up duration was 51?months (range 5-2), and the mean survival was 25.8?months (95?% CI 20.4-9.3). Overall survival rates were 81?% in the first year, 42.3?% in the third year, and 15.7?% in the fifth year. In multiple variable analysis, the most important independent risk factor for overall survival was determined as the presence of lung metastasis (HR 1.43, 95?% CI 1.27-.14; P?=?0.012). Brain metastasis develops late in the period of colorectal cancer and prognosis in these patients is poor. However, early screening of brain metastases in patients with lung metastasis may improve survival outcomes with new treatment modalities.