A facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

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• 作者：İbrahim Esirden ; Erhan Başar ; Muharrem Kaya
• 关键词：5 ; substituted 1H ; tetrazoles ; copper(I) chloride ; sodium azide ; [3 + 2] cycloaddition ; aryl nitriles
• 刊名：Chemical Papers
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：69
• 期：9
• 页码：1231-1236
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering; Biochemistry, general; Medicinal Chemistry; Materials Science, general; Biotechnology;
• 出版者：Springer International Publishing
• ISSN：1336-9075
• 卷排序：69

文摘

The present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper(I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst.