Effect of Ibutilide on the Canine Cardiac Conduction System

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• 作者：Jian Ling Sun (1)
  Rong Han (2)
  Ji Hong Guo (3)
  Xiao Ying Li (4)
  Xian Lin Ma (5)
  Chong Yu Wang (1)
  
• 关键词：Cardiology ; Ibutilide ; Canines ; Electrophysiological character ; Sinoatrial node ; Atrioventricular node
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：64
• 期：2
• 页码：161-168
• 全文大小：637KB
• 参考文献：1. Lee, K. S., & Gibson, J. K. (1995). Unique ionic mechanism of action of ibutilide on freshly isolated heart cells. / Circulation, / 92, 2755-757.
  2. Yang, T., Snyders, D. J., & Roden, D. M. (1995). Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K⁺ current ( / I _Kr) in AT-1 cells: Concentration-, time-, voltage-, and use-dependent effects. / Circulation, / 91, 1799-806. CrossRef
  3. Tai, C., Chen, S. A., Feng, A. N., Yu, W. C., Chen, Y. J., & Chang, M. S. (1998). Electropharmacologic effects of class I and class III antiarrhythmia drugs on typical atrial flutter: Insights into the mechanism of termination. / Circulation, / 97, 1935-945. CrossRef
  4. Stambler, B. S., Wood, M. A., Ellenbogen, K. A., et al. (1996). Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. / Circulation, / 94, 1613-621. CrossRef
  5. Xu, S. Y., Bian, R. L., & Chen, X. (1982). / Methodology of pharmaco-test (p. 1184). Beijing: People’s Health Publishing House.
  6. Jianling, S., Jihong, G., & Haicheng, Z. (2005). The observation of the effect of ibutilide and propafenone on cardioversion of atrial flutter. / Chinese Journal of Internal Medicine, / 2, 137-39.
  7. Jianling, S., Jihong, G., Peng, L., et al. (2005). The effect of Ibutilide on electrophysiological characteristics of canine heart. / Chinese Cardiac Pacing and Cardiac Electrophysiology Journal, / 4, 284-87.
  8. Baskin, E. P., & Lynch, J. J. (1998). Differential atrial versus ventricular activities of class III potassium channel blockers. / Journal of Pharmacology and Experimental Therapeutics, / 285, 135-42.
  9. Sato, N., Yanaka, H. T., Yoshizumi Habuchi, Y., & Giles, W. R. (2000). Electrophysiological effects of ibutilide on the delayed rectifier K⁺ current in rabbit sinoatrial and atrioventricular node cells. / European Journal of Pharmacology, / 404, 281-88. CrossRef
  10. Gowda, R. M., Punukollu, G., Khan, I. A., et al. (2003). Ibutilide for pharmacological cardioversion of atrial fibrillation and flutter: Impact of race on efficacy and safety. / American Journal of Therapeutics, / 4, 259-63. CrossRef
  11. Antonicelli, R., Testarmata, P., & Recanatini, A. (2002). Ibutilide in rapid conversion of atrial flutter in octogenarians. / Drugs and Aging, / 10, 787-91. CrossRef
  12. Lee, K. S., & Lee, E. W. (1998). Ionic mechanism of ibutilide in human atrium: Evidence for a drug induced Na⁺ current through a nifedipine inhibited inward channel. / The Journal of Pharmacology and Experimental Therapeutics, / 1, 9-2.
  13. Hongo, R. H., Themistoclakis, S., Raviele, A., et al. (2004). Use of ibutilide in cardioversion of patients with atrial fibrillation or atrial flutter treated with class IC agents. / The Journal of American College of Cardiology, / 44, 864-68. CrossRef
  
• 作者单位：Jian Ling Sun (1)
  Rong Han (2)
  Ji Hong Guo (3)
  Xiao Ying Li (4)
  Xian Lin Ma (5)
  Chong Yu Wang (1)
  
  1. Department of Cardiology, Aviation General Hospital, An Ding Men Wai Bei Yuan Road 3, Beijing, 100012, China
  2. Department of Chinese Internal Medicine, The Sixth Affiliated Hospital of Xinjiang Medical University, Wu Lu Mu Qi Wu Xing Nan Road 39, Wulumuqi, 830002, China
  3. Electrophysiology Group, Department of Cardiology, People’s Hospital, Peking University, Beijing, China
  4. Department of Geriatric Cardiology, The Chinese People’s Liberation Army General Hospital, Beijing, China
  5. Department of Cardiology, Beijing Jian Gong Hospital, Beijing, China
  

文摘

The objective of the study was to evaluate the effect of ibutilide on canine cardiac sinoatrial and atrioventricular nodes (AVNs). For this purpose, 18 mongrel dogs were injected intravenously with ibutilide and the changes in heart rate, sinus node recovery time, and AVN were measured. Our data show that ibutilide administration caused significant suppression of the sinus atrial node, the peak response time was 20-0?min, and the heart rate was restored to pre-drug administration level. After receiving ibutilide, 1 animal had a 5?s sinus pause, and after 5?min of ibutilide administration, 1 dog showed 2:1 atrioventricular conduction. Therefore, it was concluded that ibutilide had a suppressive effect on the sinoatrial node and AVN.