High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival

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• 作者：Akimitsu Yamada (1)
  Takashi Ishikawa (2)
  Ikuko Ota (2)
  Mariko Kimura (1)
  Daisuke Shimizu (2)
  Mikiko Tanabe (3)
  Takashi Chishima (1)
  Takeshi Sasaki (3)
  Yasushi Ichikawa (1)
  Satoshi Morita (4)
  Koh-ichiro Yoshiura (5)
  Kazuaki Takabe (6)
  Itaru Endo (1)
  
• 关键词：Breast cancer ; ATP ; binding cassette transporters ; ABCC11 ; Tissue microarray ; Subtype
• 刊名：Breast Cancer Research and Treatment
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：137
• 期：3
• 页码：773-782
• 全文大小：1984KB
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• 作者单位：Akimitsu Yamada (1)
  Takashi Ishikawa (2)
  Ikuko Ota (2)
  Mariko Kimura (1)
  Daisuke Shimizu (2)
  Mikiko Tanabe (3)
  Takashi Chishima (1)
  Takeshi Sasaki (3)
  Yasushi Ichikawa (1)
  Satoshi Morita (4)
  Koh-ichiro Yoshiura (5)
  Kazuaki Takabe (6)
  Itaru Endo (1)
  
  1. Department of Clinical Oncology and Breast Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan
  2. Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4-57 Urafunecho, Minami-ku, Yokohama, Kanagawa, Japan
  3. Department of Pathology, Yokohama City University Medical Center, 4-57 Urafunecho, Minami-ku, Yokohama, Kanagawa, Japan
  4. Department of Biostatics and Epidemiology, Yokohama City University Medical Center, 4-57 Urafunecho, Minami-ku, Yokohama, Kanagawa, Japan
  5. Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, Japan
  6. Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, 7-402 West Hospital, 1200 E Broad Street, Richmond, VA, USA
  
• ISSN：1573-7217

文摘

ATP-binding cassette (ABC) transporters are membrane proteins that efflux various compounds from cells, including chemotherapeutic agents, and are known to affect multidrug resistance. Recent reports disagree on whether ABCC11 is a risk factor for breast tumorigenesis, but its expression in breast cancer is poorly investigated. We hypothesized that both frequency and expression levels of ABC transporters in breast tumors would vary by cancer subtype, and be associated with prognosis. Here, we constructed a tissue microarray breast tumor samples from 281 patients, and analyzed expressions of ABCB1, ABCC1, ABCC11, and ABCG2 immunohistochemically. Breast cancer subtypes were determined by immunohistochemistry of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2). Protein expression was correlated to clinicopathological characteristics, clinical follow-up, and pathological complete response to neoadjuvant chemotherapy. The tissue microarray comprised 191 luminal A (68.0?%), 17 luminal B (6.0?%), 27?HER2 (9.6?%), and 46 triple-negative (16.4?%) samples. ABCC1 and ABCC11 expressions were associated with significantly shorter disease-free survival (P?=?0.027 and P?=?0.003, respectively). ABCC1, ABCC11, and ABCG2, but not ABCB1, were expressed significantly more, and more frequently, in aggressive subtypes. Patients with HER2+ and triple-negative tumor subtypes that expressed high levels of ABCC11 had significantly worse disease-free survival (P?=?0.017 and P?<?0.001, respectively). We have shown, for the first time, that ABCC1, ABCC11, and ABCG2 are highly expressed in aggressive breast cancer subtypes, and that tumor ABCC11 expression is associated with poor prognosis.