Imaging mass spectrometry of elements in forensic cases by LA-ICP-MS
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- 作者：Estelle Lauer ; Max Villa ; Morgane Jotterand…
- 关键词：Imaging mass spectrometry ; LA ; ICP ; Metal ; Tissue section ; Histology ; Trace elements
- 刊名：International Journal of Legal Medicine
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：131
- 期：2
- 页码：497-500
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Forensic Medicine; Medical Law; Medicine/Public Health, general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1437-1596
- 卷排序：131
文摘
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was performed to map elements in thin formalin-fixed paraffin-embedded tissue sections of two forensic cases with firearm and electrocution injuries, respectively. In both cases, histological examination of the wounded tissue regions revealed the presence of exogenous aggregates that may be interpreted as metallic depositions. The use of imaging LA-ICP-MS allowed us to unambiguously determine the elemental composition of the observed aggregates assisting the pathologist in case assessments. To the best of our knowledge, we demonstrate for the first time the use of imaging LA-ICP-MS as a complementary tool for forensic pathologists and toxicologists in order to map the presence of metals and other elements in thin tissue sections of post-mortem cases.