Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary fibrosis: a case control study
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- 作者：Jun Fukihara ; Hiroyuki Taniguchi ; Masahiko Ando ; Yasuhiro Kondoh…
- 关键词：Hemosiderin ; laden macrophages ; Idiopathic pulmonary fibrosis ; Pulmonary vascular resistance ; Mean pulmonary arterial pressure ; Bronchoalveolar ; lavage ; Right heart catheterization
- 刊名：BMC Pulmonary Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：762KB
- 刊物主题：Pneumology/Respiratory System; Internal Medicine; Intensive / Critical Care Medicine;
- 出版者：BioMed Central
- ISSN：1471-2466
- 卷排序：17
文摘
BackgroundIncreases in hemosiderin-laden macrophages (HLM) are reported to be observed in idiopathic pulmonary fibrosis (IPF). According to a recent study, significant correlation between hemosiderin deposition in the lung tissue of IPF and pulmonary hypertension evaluated by echocardiography has been suspected. In this study, we aimed to evaluate whether HLM in bronchoalveolar lavage fluid (BALF) is a factor correlated with pulmonary hemodynamic parameters evaluated by right heart catheterization in patients with IPF.