Novel Gene Associations in Type 1 Diabetes

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• 作者：Jorma Ilonen (1) (2)
  Robert Hermann (1)
  
• 关键词：Type 1 diabetes ; Susceptibility genes ; HLA region ; Non ; HLA genes ; Genetic prediction ; Disease pathways ; Immune tolerance ; Prevention of type 1 diabetes ; Gene environment interactions ; Integrated genomics
• 刊名：Current Diabetes Reports
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：10
• 期：5
• 页码：338-344
• 全文大小：164KB
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• 作者单位：Jorma Ilonen (1) (2)
  Robert Hermann (1)
  
  1. Immunogenetics Laboratory, University of Turku, Tykist?katu 6A, 20520, Turku, Finland
  2. Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland
  

文摘

Recent genome-wide association studies have been able to identify multiple new gene loci affecting type 1 diabetes susceptibility, but the impact of these new defined loci seems to decrease in parallel with their number. The HLA gene region remains the main nominator of genetic susceptibility, although the identity of important genes and especially the mechanisms of their action are still largely unclear. Products of HLA and most other known risk genes are involved in regulation of the immune system in accordance with the autoimmune nature of the disease. The multitude of genes involved in the pathogenesis implies complex pathways where multiple steps in each may be essential in turning the balance of immune response to β-cell destructing autoimmunity.