Multimodal Imaging Reveals Improvement of Blood Supply to an Artificial Cell Transplant Site Induced by Bioluminescent Mesenchymal Stem Cells

详细信息    查看全文

• 作者：Andrea Gálisová ; Eva Fábryová ; Daniel Jirák ; Eva Sticová…
• 关键词：Key wordsMagnetic resonance imaging ; Dynamic contrast ; enhanced MRI ; DCE ; Bioluminescence ; Mesenchymal stem cells ; Vascularisation
• 刊名：Molecular Imaging and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：15-23
• 全文大小：7017KB
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：19

文摘

PurposeAn artificial site for cell or pancreatic islet transplantation can be created using a polymeric scaffold, even though it suffers subcutaneously from improper vascularisation. A sufficient blood supply is crucial for graft survival and function and can be enhanced by transplantation of mesenchymal stem cells (MSCs). The purpose of this study was to assess the effect of syngeneic MSCs on neoangiogenesis and cell engraftment in an artificial site by multimodal imaging.