The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila

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• 作者：Dondra Bailey ; Mohammed Abul Basar ; Sanjay Nag…
• 关键词：Drosophila ; Peroxidase ; Wing development ; Oxidase ; Cysu
• 刊名：BMC Developmental Biology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：2438KB
• 刊物主题：Developmental Biology; Animal Models; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-213X
• 卷排序：17

文摘

BackgroundThus far, a handful of genes have been shown to be related to the wing maturation process in insects. A novel heme peroxidase enzyme known as curly suppressor (Cysu)(formerly CG5873), have been characterized in this report because it is involved in wing morphogenesis. Using bioinformatics tools we found that Cysu is remarkably conserved in the genus Drosophila (>95%) as well as in invertebrates (>70%), although its vertebrate orthologs show poor homology. Time-lapse imaging and histochemical analyses have confirmed that the defective wing phenotype of Cysu is not a result of any underlying cellular alterations; instead, its wings fail to expand in mature adults.