Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

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• 作者：Gabor G. Kovacs ; Isidro Ferrer ; Lea T. Grinberg ; Irina Alafuzoff…
• 关键词：Aging ; ARTAG ; Tau astrogliopathy ; Tau
• 刊名：Acta Neuropathologica
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：131
• 期：1
• 页码：87-102
• 全文大小：3,089 KB
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• 作者单位：Gabor G. Kovacs (1)
  Isidro Ferrer (2)
  Lea T. Grinberg (3) (4)
  Irina Alafuzoff (5)
  Johannes Attems (6)
  Herbert Budka (7)
  Nigel J. Cairns (8)
  John F. Crary (33) (9)
  Charles Duyckaerts (10)
  Bernardino Ghetti (11)
  Glenda M. Halliday (12)
  James W. Ironside (13)
  Seth Love (14)
  Ian R. Mackenzie (15)
  David G. Munoz (16)
  Melissa E. Murray (17)
  Peter T. Nelson (18)
  Hitoshi Takahashi (19)
  John Q. Trojanowski (20)
  Olaf Ansorge (21)
  Thomas Arzberger (22)
  Atik Baborie (23)
  Thomas G. Beach (24)
  Kevin F. Bieniek (17)
  Eileen H. Bigio (25)
  Istvan Bodi (26)
  Brittany N. Dugger (24) (27)
  Mel Feany (28)
  Ellen Gelpi (29)
  Stephen M. Gentleman (30)
  Giorgio Giaccone (31)
  Kimmo J. Hatanpaa (32)
  Richard Heale (6)
  Patrick R. Hof (33)
  Monika Hofer (21)
  Tibor Hortobágyi (34)
  Kurt Jellinger (35)
  Gregory A. Jicha (36)
  Paul Ince (37)
  Julia Kofler (38)
  Enikö Kövari (39)
  Jillian J. Kril (40)
  David M. Mann (41)
  Radoslav Matej (42)
  Ann C. McKee (43)
  Catriona McLean (44)
  Ivan Milenkovic (1) (45)
  Thomas J. Montine (46)
  Shigeo Murayama (47)
  Edward B. Lee (20)
  Jasmin Rahimi (1)
  Roberta D. Rodriguez (48)
  Annemieke Rozemüller (49)
  Julie A. Schneider (50) (51)
  Christian Schultz (52)
  William Seeley (3)
  Danielle Seilhean (10)
  Colin Smith (13)
  Fabrizio Tagliavini (31)
  Masaki Takao (53)
  Dietmar Rudolf Thal (54) (55)
  Jon B. Toledo (20)
  Markus Tolnay (56)
  Juan C. Troncoso (57)
  Harry V. Vinters (58) (59)
  Serge Weis (60)
  Stephen B. Wharton (37)
  Charles L. White III (32)
  Thomas Wisniewski (61) (62) (63)
  John M. Woulfe (64)
  Masahito Yamada (65)
  Dennis W. Dickson (17)
  
  1. Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097, Vienna, Austria
  2. Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain
  3. Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
  4. Department of Pathology, LIM-22, University of Sao Paulo Medical School, Sao Paulo, Brazil
  5. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  6. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
  7. Institute of Neuropathology, University Hospital Zürich, Zurich, Switzerland
  8. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
  33. Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
  9. Department of Pathology, Friedman Brain Institute, and the Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, USA
  10. Neuropathology Department, Hopital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France
  11. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
  12. GMH-Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia
  13. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
  14. Institute of Clinical Neurosciences, University of Bristol, Learning and Research Level 2, Southmead Hospital, Bristol, UK
  15. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
  16. Division of Pathology, St. Michael’s Hospital, 30 Bond St, Toronto, ON, Canada
  17. Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA
  18. Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA
  19. Department of Pathology, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan
  20. Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA
  21. Department of Neuropathology, John Radcliffe Hospital, Oxford, UK
  22. Department of Psychiatry and Psychotherapy, Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany
  23. Department of Neuropathology, Walton Centre, Liverpool, UK
  24. Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, 85351, USA
  25. Northwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  26. Clinical Neuropathology, King’s College Hospital, London Neurodegenerative Brain Bank, London, UK
  27. Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA
  28. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  29. Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d’Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
  30. Department of Medicine, Imperial College London, London, UK
  31. IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy
  32. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
  34. Department of Neuropathology, Faculty of Medicine, Institute of Pathology, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary
  35. Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150, Vienna, Austria
  36. Department of Neurology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA
  37. Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
  38. Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
  39. Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland
  40. Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia
  41. Institute of Brain, Behaviour and Mental Health, Manchester University Faculty of Medical and Health Sciences, Manchester, UK
  42. Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague 4, Czech Republic
  43. Department of Neurology and Pathology, Boston University School of Medicine and VA Healthcare System, Boston, MA, 02118, USA
  44. Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC, 3004, Australia
  45. Department of Neurology, Medical University of Vienna, Vienna, Austria
  46. Department of Pathology, University of Washington, Seattle, WA, USA
  47. Department of Neuropathology (The Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
  48. Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil
  49. Netherlands Brainbank and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
  50. Department of Pathology, Rush University Medical Center, Chicago, IL, USA
  51. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
  52. Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
  53. Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan
  54. Laboratory of Neuropathology, Institute of Pathology, University of Ulm, 89081, Ulm, Germany
  55. Department of Neuroscience, KU-Leuven, 3000, Louvain, Belgium
  56. Institute of Pathology, University Hospital Basel, Basel, Switzerland
  57. Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  58. Section of Neuropathology, Department of Pathology and Laboratory Medicine, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA
  59. Department of Neurology, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA
  60. Department of Pathology and Neuropathology, Laboratory of Neuropathology, Neuromed Campus, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria
  61. Department of Neurology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY, 10016, USA
  62. Department of Pathology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY, 10016, USA
  63. Department of Psychiatry, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY, 10016, USA
  64. Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada
  65. Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0533

文摘

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators. Keywords Aging ARTAG Tau astrogliopathy Tau