Advanced magnetic resonance imaging of neurodegenerative diseases
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- 作者：Federica Agosta ; Sebastiano Galantucci ; Massimo Filippi
- 关键词：Magnetic resonance imaging ; Atrophy ; Diffusion tensor MRI ; Resting state functional MRI ; Alzheimer’s disease ; Dementia with Lewy bodies ; Frontotemporal dementia ; Primary progressive aphasia ; Parkinson’s disease
- 刊名：Neurological Sciences
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：38
- 期：1
- 页码：41-51
- 全文大小：2264KB
- 刊物类别：Medicine
- 刊物主题：Neurology; Neuroradiology; Neurosurgery; Psychiatry;
- 出版者：Springer Milan
- ISSN：1590-3478
- 卷排序：38
文摘
Magnetic resonance imaging (MRI) is playing an increasingly important role in the study of neurodegenerative diseases, delineating the structural and functional alterations determined by these conditions. Advanced MRI techniques are of special interest for their potential to characterize the signature of each neurodegenerative condition and aid both the diagnostic process and the monitoring of disease progression. This aspect will become crucial when disease-modifying (personalized) therapies will be established. MRI techniques are very diverse and go from the visual inspection of MRI scans to more complex approaches, such as manual and automatic volume measurements, diffusion tensor MRI, and functional MRI. All these techniques allow us to investigate the different features of neurodegeneration. In this review, we summarize the most recent advances concerning the use of MRI in some of the most important neurodegenerative conditions, putting an emphasis on the advanced techniques.