Synthesis of 3-aminomethyl-4-hydroxycoumarins and their retro-Mannich reaction in dimethyl sulfoxide

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• 作者：B. G. Milevskii ; T. A. Chibisova ; N. P. Solov′eva…
• 关键词：4 ; hydroxycoumarin derivatives ; imines ; enamines ; hydrogenation ; aminomethylcoumarins ; retro ; Mannich reaction ; dicoumarol
• 刊名：Russian Chemical Bulletin
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：64
• 期：2
• 页码：423-428
• 全文大小：331 KB
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• 作者单位：B. G. Milevskii (1)
  T. A. Chibisova (1)
  N. P. Solov′eva (1)
  A. Yu. Sukhorukov (2)
  V. F. Traven (1)
  
  1. D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya pl., 125047, Moscow, Russian Federation
  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9171

文摘

Hydrogenation of 3-formyl-4-hydroxycoumarin aliphatic imines leads to 3-aminomethyl-4-hydroxycoumarins, which undergo a retro-Mannich reaction in dimethyl sulfoxide containing even traces of water. Keywords 4-hydroxycoumarin derivatives imines enamines hydrogenation aminomethylcoumarins retro-Mannich reaction dicoumarol