Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

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• 作者：Radim Geryk ; Květa Kalíková ; Ji?í Vozka ; Eva Tesa?ová
• 关键词：Normal phase mode ; Reversed phase mode ; Enantioselective potential ; Immobilized polysaccharide ; based chiral stationary phases ; Amylose ; Cellulose
• 刊名：Chromatographia
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：78
• 期：13-14
• 页码：909-915
• 全文大小：471 KB
• 参考文献：1.Mohan SJ, Mohan EC, Yamsani MR (2009) Int J Pharm Sci Nanotechnol 1:309-16
  2.Schwaninger AE, Meyer MR, Maurer HH (2012) J Chromatogr A 1269:122-35View Article
  3.Kalíková K, ?lechtová T, Vozka J, Tesa?ová E (2014) Anal Chim Acta 821:1-3View Article
  4.Ribeiro AR, Maia AS, Cass QB, Tiritan ME (2014) J Chromatogr B 968:8-1View Article
  5.Kalíková K, Riesová M, Tesa?ová E (2012) Cent Eur J Chem 10:450-71View Article
  6.Chankvetadze B (2012) J Chromatogr A 1269:26-1View Article
  7.Zhang T, Franco P, Nguyen D, Hamasaki R, Miyamoto S, Ohnishi A, Murakami T (2012) J Chromatogr A 1269:178-88View Article
  8.Geryk R, Vozka J, Kalíková K, Tesa?ová E (2013) Chromatographia 76:483-89View Article
  9.Shen J, Ikai T, Okamoto Y (2014) J Chromatogr A 1363:51-1View Article
  10.Rahou I, Belboukhari N, Sekkoum K, Cheriti A, Aboul-Enein HY (2014) Chromatographia 77:1195-201View Article
  11.Zhang T, Nguyen D, Franco P (2010) J Chromatogr A 1217:1048-055View Article
  12.Ku?erová G, Vozka J, Kalíková K, Geryk R, Plecitá D, Pajpanova T, Tesa?ová E (2013) Sep Purif Technol 119:123-28View Article
  13.Geryk R, Kalíková K, Vozka J, Plecitá D, Schmid MG, Tesa?ová E (2014) J Chromatogr A 1363:155-61View Article
  14.L?mmerhofer M (2010) J Chromatogr A 1217:814-56View Article
  
• 作者单位：Radim Geryk (1)
  Květa Kalíková (1)
  Ji?í Vozka (1)
  Eva Tesa?ová (1)
  
  1. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, Albertov 2030, 12843, Prague, Czech Republic
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Organic Chemistry
  Pharmacy
  Biochemistry
  Plant Sciences
  Measurement Science and Instrumentation
  
• 出版者：Vieweg Verlag
• ISSN：1612-1112

文摘

A set of 31 structurally different chiral pharmaceutical compounds was used as model analytes for investigation of the enantioselective potential of two immobilized polysaccharide-based chiral stationary phases under normal and reversed phase separation conditions. These chiral stationary phases differed in the polymeric backbone, amylose or cellulose, but possessed the same derivatization functionality. The results showed that the tris(3,5-dimethylphenylcarbamate) of amylose and cellulose have very broad, and often complementary, enantiorecognition abilities. In general, normal phase separation mode seemed to be more advantageous for separation of the majority of studied pharmaceuticals no matter if amylose- or cellulose-based columns were used. However, in certain cases the reversed phase separation system yielded better results. The combination of these two immobilized chiral stationary phases offers a powerful tool for enantioseparation of different types of pharmaceuticals in the normal and/or reversed phase mode.