The activation of the IFNβ induction/signaling pathway in porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus is variable

详细信息    查看全文

• 作者：Christopher C. Overend ; Junru Cui ; Marvin J. Grubman…
• 关键词：Porcine reproductive respiratory syndrome virus ; Interferon beta ; Mx ; 1 innate immunity
• 刊名：Veterinary Research Communications
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：41
• 期：1
• 页码：15-22
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Zoology; Veterinary Medicine/Veterinary Science;
• 出版者：Springer Netherlands
• ISSN：1573-7446
• 卷排序：41

文摘

BackgroundIt has been recognized that the expression of type I interferon (IFNα/β) may be suppressed during infection with porcine reproductive, respiratory syndrome virus (PRRSV). This causes profound negative effects on both the innate and adaptive immunity of the host resulting in persistence of infection.