Mesenchymale Stamm-/Stromazellen
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- 作者：PD Dr. R. Schäfer ; PD Dr. T. Daikeler
- 关键词：SchlüsselwörterSystemische Sklerose ; Systemischer Lupus erythematodes ; Transplantation ; Immunmodulation ; Immunsuppression
- 刊名：Zeitschrift f¨¹r Rheumatologie
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：75
- 期：8
- 页码：786-794
- 全文大小：249 KB
- 刊物主题：Internal Medicine; Rheumatology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1435-1250
- 卷排序：75
文摘
Mesenchymal stem and stromal cells (MSC) are propagated for the treatment of autoimmune and autoinflammatory processes. These cells can be relatively easily obtained from various tissues. The MSC feature anti-inflammatory and immunosuppressive properties in vitro as well as in animal models. Initial reports on the clinical application of MSC for various diseases are available, some with promising results and so far no reported toxicity; however, data from phase III studies are still lacking and crucial questions are still unanswered. The MSC preparations used are heterogeneous and also differ depending on the source and it is unclear whether autologous (own) or allogeneic (foreign) MSC are more suitable for therapeutic use. Long-term consequences, such as possible malignant transformation and possible endogenous tumor growth stimulation cannot be completely excluded. Ultimately, these questions can only be answered through randomized controlled trials for defined clinical indications with defined MSC.