Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer
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- 作者：Emmanuel Zervos ; Steven Agle…
- 关键词：Mesothelin ; Pancreas ; Tumor ; Proliferation ; Immune
- 刊名：Journal of Experimental & Clinical Cancer Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：35
- 期：1
- 全文大小：2,576 KB
- 刊物主题：Oncology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-9966
文摘
Background Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothelin in immunocompromised mice. Since these models do not allow for study of the natural immune response to mesothelin expressing tumors, we have undertaken the characterization of mouse mesothelin so the effects of this protein can be assessed in immunocompetent mouse strains.