Differential replicative ability of clinical dengue virus isolates in an immunocompetent C57BL/6 mouse model
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- 作者：Veridiana Ester Barros ; Nilton Nascimento dos Santos-Junior…
- 关键词：Dengue virus ; Animal model ; Antibody dependent enhancement ; Clinical isolates
- 刊名：BMC Microbiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,693 KB
- 刊物主题：Microbiology; Biological Microscopy; Fungus Genetics; Parasitology; Virology; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2180
文摘
Background Several experimental animal models have been used to study the pathogenesis of dengue disease; however, most of the studies used laboratory-adapted viruses, which lack the virulence of viruses circulating in humans. The aim of this study was to analyze the ability of clinical Dengue virus (DENV) isolates (D2/BR/RP/RMB/09 and D3/BR/SL3/02) to infect immunocompetent C57BL/6 mice.