Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo
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- 作者：Hong-ying Gao (1)
Guo-yu Li (2)
Jian Huang (1)
Ying Han (3)
Fu-zhou Sun (1)
Xiao-wei Du (3)
Li-juan An (3)
Hang-yu Wang (2)
Jin-hui Wang (1) (2) - 关键词：Zhuyeqing liquor ; Immune function ; Antioxidant effects ; Cyclophosphamide
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：190 KB
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31. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/252/prepub - 作者单位：Hong-ying Gao (1)
Guo-yu Li (2)
Jian Huang (1)
Ying Han (3)
Fu-zhou Sun (1)
Xiao-wei Du (3)
Li-juan An (3)
Hang-yu Wang (2)
Jin-hui Wang (1) (2)
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China
2. School of Pharmacy, Shihezi University, Shihezi, 832002, P.R. China
3. Shanxi Xinghuacun Fen Jiu Group Co. Ltd, Shanxi, 450000, P.R. China - ISSN：1472-6882
文摘
Background Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects. Methods The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in vivo in normal healthy mice and immunosuppressed mice treated with Cyclophosphamide (Cy, 100?mg/kg) by intraperitoneal injection on days 4, 8 and 12. ZYQL (100, 200 and 400?mg/kg) was administered via gavage daily for 14?days. The phagocytotic function of mononuclear phagocytic system was detected with carbon clearance methods, the levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in serum were detected with Enzyme linked immunosorbent assay (ELISA). Immune organs were weighed and organ indexes (organ weight/body weight) of thymus and spleen were calculated. Meanwhile, the activity of lysozyme (LSZ) in serum and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) in spleen tissue were measured. Results ZYQL significantly upgrades the K value for clearance of carbon particles in normal mice treated with ZYQL (400?mg/kg) and immunosuppressed mice treated with ZYQL (100, 200 and 400?mg/kg) together with Cy (100?mg/kg) in vivo. The treatment of ZYQL (100, 200 and 400?mg/kg) effectively increased the activity of serum lysozyme as well as promoted the serum levels of IL-6 and IFN-γ in normal mice and immunosuppressed mice. Furthermore, ZYQL (100, 200 and 400?mg/kg) had an antioxidant effects in immune system by enhancing the antioxidant enzyme activity of SOD, CAT and GSH-Px in vivo. In addition, ZYQL (100, 200 and 400?mg/kg) effectively elevated the Cy-induced decreased organ index (thymus and spleen). Conclusions The present work shows that the dose-dependent administration of ZYQL is capable of influencing immune responses, which implying that its valuable functional health may be attributed partly to its protective effects for the immune function.