Phellinus baumii ethyl acetate extract alleviated collagen type II induced arthritis in DBA/1 mice

详细信息    查看全文

• 作者：Taddesse Yayeh (1)
  Whi Min Lee (1)
  Dukhwan Ko (8)
  Seung-Choon Park (1)
  Jae Youl Cho (2)
  Hwa-Jin Park (3)
  In-Kyoung Lee (4)
  Seung-Hyung Kim (5)
  Seung-Bok Hong (6)
  Suk Kim (7)
  Bong-Sik Yun (4)
  Man Hee Rhee (1)
  
• 关键词：Phellinus baumii ; Leukocytes ; Collagen type II induced arthritis ; Mice
• 刊名：Journal of Natural Medicines
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：67
• 期：4
• 页码：807-813
• 全文大小：561KB
• 参考文献：1. Imboden JB (2009) The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol 4:417-34 CrossRef
  2. Isaacs JD (2010) The changing face of rheumatoid arthritis: sustained remission for all? Nat Rev Immunol 10:605-11 CrossRef
  3. Brand DD, Kang AH, Rosloniec EF (2003) Immunopathogenesis of collagen arthritis. Springer Semin Immunopathol 25:3-8 CrossRef
  4. Holmdahl R, Bockermann R, B?cklund J, Yamada H (2002) The molecular pathogenesis of collagen-induced arthritis in mice—a model for rheumatoid arthritis. Ageing Res Rev 1:135-47 CrossRef
  5. Szekanecz Z, Koch AE (2007) Macrophages and their products in rheumatoid arthritis. Curr Opin Rheumatol 19:289-95 CrossRef
  6. Toh ML, Miossec P (2007) The role of T cells in rheumatoid arthritis: new subsets and new targets. Curr Opin Rheumatol 19:284-88 CrossRef
  7. Aggarwal A (2009) Are B cells important in pathogenesis of RA? Ind J Rheumatol 4:1- CrossRef
  8. Feldmann M (2009) Translating molecular insights in autoimmunity into effective therapy. Annu Rev Immunol 27:1-7 CrossRef
  9. McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-42 CrossRef
  10. Raval G, Mehta P (2010) TNF-alpha inhibitors: are they carcinogenic? Drug Healthc Patient Saf 2:241-47
  11. Cheung PCK (2010) The nutritional and health benefits of mushrooms. BNF Nutr Bull 35:292-99 CrossRef
  12. Noh JR, Lee IK, Ly SY, Yang KJ, Gang GT, Kim YH, Hwang JH, Yun BS, Lee CH (2011) A / Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice. J Med Food 14:209-18 CrossRef
  13. Lee I-K, Han M-S, Lee M-S, Kim Y-S, Yun B-S (2010) Styrylpyrones from the medicinal fungus / Phellinus baumii and their antioxidant properties. Bioorg Med Chem Lett 20:5459-461 CrossRef
  14. Hwang HJ, Kim SW, Lim JM, Joo JH, Kim HO, Kim HM, Yun JW (2005) Hypoglycemic effect of crude exopolysaccharides produced by a medicinal mushroom / Phellinus baumii in streptozotocin-induced diabetic rats. Life Sci 76:3069-080 CrossRef
  15. Kamruzzaman SM, Endale M, Oh WJ, Park SC, Kim TH, Lee IK, Cho JY, Park HJ, Kim SK, Yun BS, Rhee MH (2011) Antiplatelet activity of / Phellinus baumii methanol extract is mediated by cyclic AMP elevation and inhibition of collagen-activated integrin-alpha(IIb) beta and MAP kinase. Phytother Res 25:1596-603 CrossRef
  16. Yayeh T, Oh WJ, Park SC, Kim TH, Cho JY, Park HJ, Lee IK, Kim SK, Hong SB, Yun BS, Rhee MH (2012) / Phellinus baumii ethyl acetate extract inhibits lipopolysaccharide-induced iNOS, COX-2, and proinflammatory cytokine expression in RAW264.7 cells. J Nat Med 66:49-4 CrossRef
  17. Yayeh T, Jung K-H, Jeong HY, Park J-H, Song Y-B, Kwak Y-S, Kang H-S, Cho JY, Oh J-W, Kim S-K, Rhee MH (2012) Korean Red Ginseng Saponin Fraction downregulates proinflammatory mediators in LPS stimulated RAW264.7 cells and protects mice against endotoxic shock. J Ginseng Res 36:263-69 CrossRef
  18. Brand DD, Latham KA, Rosloniec EF (2007) Collagen-induced arthritis. Nat Protoc 2:1269-275 CrossRef
  19. Panayi GS (2005) B cells: a fundamental role in the pathogenesis of rheumatoid arthritis? Rheumatology 44:3- CrossRef
  20. Brennan F, Beech J (2007) Update on cytokines in rheumatoid arthritis. Curr Opin Rheumatol 19:296-01 CrossRef
  21. Feldmann M (2002) Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol 2:364-71 CrossRef
  22. Jin J, Chang Y, Wei W (2010) Clinical application and evaluation of anti-TNF-alpha agents for the treatment of rheumatoid arthritis. Acta Pharmacol Sin 31:1133-140 CrossRef
  23. Taylor PC (2011) Developing anti-TNF and biologic agents. Rheumatology (Oxford) 50:1351-353 CrossRef
  24. Chang SH, Sung HC, Choi Y, Ko SY, Lee BE, Baek DH, Kim SW, Kim JK (2005) Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice. Int Immunopharmacol 5:1365-372 CrossRef
  25. Lee YC, Kim SH, Roh SS, Choi HY, Seo YB (2007) Suppressive effects of / Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice. J Ethnopharmacol 112:40-8 CrossRef
  26. Zhou X, Zhao X, Tang L, Zhang Y, Ruan H, Pi H, Qiu J, Wu J (2007) Immunomodulatory activity of the rhizomes of / Impatiens pritzellii var. / hupehensis on collagen-induced arthritis mice. J Ethnopharmacol 109:505-09 CrossRef
  27. Adams A, Lehman TJ (2005) Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis. Curr Opin Rheumatol 17:612-16 CrossRef
  28. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (2000) TAB 2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 5:649-58 CrossRef
  29. Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, Zafarullah M (2003) Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp Cell Res 288:208-17 CrossRef
  30. Cronstein BN (2005) Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev 57:163-72 CrossRef
  31. Chan ES, Cronstein BN (2002) Molecular action of methotrexate in inflammatory diseases. Arthritis Res 4:266-73 CrossRef
  32. Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M (2006) Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117:289-00 CrossRef
  33. Valencia X, Lipsky PE (2007) CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Nat Clin Pract Rheum 3:619-26 CrossRef
  
• 作者单位：Taddesse Yayeh (1)
  Whi Min Lee (1)
  Dukhwan Ko (8)
  Seung-Choon Park (1)
  Jae Youl Cho (2)
  Hwa-Jin Park (3)
  In-Kyoung Lee (4)
  Seung-Hyung Kim (5)
  Seung-Bok Hong (6)
  Suk Kim (7)
  Bong-Sik Yun (4)
  Man Hee Rhee (1)
  
  1. Laboratory of Veterinary Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea
  8. Department of Orthopaedic Surgery, Medical School, Konkuk University, Chungju, Republic of Korea
  2. School of Life science and Biotechnology, Sungkyunkwan University, Suwon, 440-746, Republic of Korea
  3. College of Biomedical Science and Engineering, Regional Research Center, Inje University, Gimhae, 621-749, Republic of Korea
  4. College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, 570-752, Republic of Korea
  5. Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, 300-716, Republic of Korea
  6. Department of Clinical Laboratory Science, Chungbuk Health and Science University, Chungbuk, 363-794, Republic of Korea
  7. College of Veterinary Medicine, Gyeongsang National University, Jinju, 660-701, Republic of Korea
  
• ISSN：1861-0293

文摘

Mushrooms have a long history of dietary benefits in Asia due to their health-promoting effects. Phellinus baumii, a wild mushroom, has been reported to have anti-platelet, anti-inflammatory, anti-obesity and free radical scavenging activities. However, its anti-rheumatoid arthritis (RA) property remains poorly understood. Hence, we investigated the protective effect of Phellinus baumii ethyl acetate extract (PBEAE) against bovine collagen type II induced arthritis (CIA) in DBA/1 mice. PBEAE (50 and 150?mg/kg) reduced the CIA score and leukocyte count in draining lymph nodes (DLNs) and inflamed joints. PBEAE also attenuated the expressions of CD3+ (T cells), CD19+ (B cells), CD4+ (T-helper), CD8+ (T-cytotoxic), MHC class II/CD11c+ (antigen-presenting cells), double positives (B220+/CD23+ and CD3+/CD69+: early lymphocyte activation markers) and CD4+/CD25+ (activated T-helper) leukocyte subpopulations in DLNs. Likewise, CD3+ and Gr-1+CD11b+ (neutrophil) counts in inflamed joints were also decreased. Furthermore, PBEAE reduced the serum levels of anti-collagen type immunoglobulin G, tumor necrosis factor-α and interleukin (IL)-1β and IL-6. Taken together, PBEAE impaired cellular recruitment to the inflamed joint and alleviated CIA, and thus could be considered as a potential agent against rheumatoid arthritis