Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction

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• 作者：Jung-Sik Kim (2) (3)
  Inho Choi (4)
  Han-Hyoung Lee (1)
  Suk Jun Lee (1)
  Manheum Na (1)
  Sang-Hoon Kim (1)
  Jihye Han (1)
  Joonbeom Bae (1)
  Sang-Pil Choi (1)
  Sang Joon Kim (3) (5)
  Chung-Gyu Park (2) (3)
  Taehoon Chun (1)
  
• 关键词：Allogeneic response ; Co ; stimulatory molecule ; Cytotoxic T lymphocyte ; associated antigen ; 4 ; Mixed lymphocyte reaction ; Rhesus monkey ; T cells
• 刊名：Biotechnology Letters
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：34
• 期：12
• 页码：2191-2197
• 全文大小：365KB
• 参考文献：1. Bour-Jordan H, Bluestone JA (2009) Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev 229:41-6 CrossRef
  2. Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P (1987) A new member of the immunoglobulin superfamily-CTLA-4. Nature 328:267-70 CrossRef
  3. Chambers CA, Kuhns MS, Egen JG, Allison JP (2001) CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Ann Rev Immunol 19:565-94 CrossRef
  4. Chen YQ, Shi HZ (2006) CD28/CTLA-4-CD80/CD86 and ICOS-B7RP-1 costimulatory pathway in bronchial asthma. Allergy 61:15-6 CrossRef
  5. Emamaullee J, Toso C, Merani S, Shapiro AM (2009) Costimulatory blockade with belatacept in clinical and experimental transplantation-a review. Expert Opin Biol Ther 9:789-96 CrossRef
  6. Fife BT, Bluestone JA (2008) Control of peripheral T-cell tolerance and autoimmunity via CTLA-4 and PD-1 pathways. Immunol Rev 224:166-82 CrossRef
  7. Greenaway HY, Kurniawan M, Price DA, Douek DC, Davenport MP, Venturi V (2009) Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes. Immunol Cell Biol 87:546-53 CrossRef
  8. Gujer C, Sundling C, Seder RA, Karlsson Hedestam GB, Lore K (2011) Human rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation. Immunology 134:257-69 CrossRef
  9. Hein WR, Griebel PJ (2003) A road less traveled: Large animal models in immunological research. Nat Rev Immunol 3:79-4 CrossRef
  10. Kim SS, Byun HJ, Kim SH, Lee HH, Lee SJ, Kim SJ, Park CG, Chun T (2010) Soluble pig lymphocyte activation gene-3 (LAG-3; CD223) inhibits human-to-pig xenogeneic mixed lymphocyte reaction. Biotechnol Lett 32:203-08 CrossRef
  11. Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobert E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Turk LA, Bajorath J, Townsend R, Hagerty D, Linsley PS, Peach RJ (2005) Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA-4Ig with potent immunosuppressive properties. Am J Transplant 5:443-53 CrossRef
  12. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA (1992) Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257:789-92 CrossRef
  13. Messaoudi I, Estep R, Robinson B, Wong SW (2011) Nonhuman primate models of human immunology. Antioxid Redox Signal 14:261-73 CrossRef
  14. Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS (1997) Soluble structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28. Nat Struct Biol 4:527-31 CrossRef
  15. Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG (2000) Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290:816-19 CrossRef
  16. Ramothea L, Webster RPJ (2005) Delineation of multiple subpopulations of natural killer cells in / rhesus macaques. Immunology 115:206-14 CrossRef
  17. Vaughan AN, Malde P, Rogers NJ, Jackson IM, Lechler RI, Dorling A (2000) Porcine CTLA-4Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4?+?T cell responses costimulated by pig but not human B7. J Immunol 165:3175-181
  18. Zhu S, Liu S, Wan L, Yang G, Yang H, Cheng J, Lu X (2011) Molecular cloning, expression and characterization of the functional domain of CTLA4 from the rhesus monkey, / Macaca mulatta. Dev Comp Immunol 35:736-44 CrossRef
  
• 作者单位：Jung-Sik Kim (2) (3)
  Inho Choi (4)
  Han-Hyoung Lee (1)
  Suk Jun Lee (1)
  Manheum Na (1)
  Sang-Hoon Kim (1)
  Jihye Han (1)
  Joonbeom Bae (1)
  Sang-Pil Choi (1)
  Sang Joon Kim (3) (5)
  Chung-Gyu Park (2) (3)
  Taehoon Chun (1)
  
  2. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, 110-799, Republic of Korea
  3. Xenotransplantation Research Center, Seoul National University Hospital, Seoul, 110-799, Republic of Korea
  4. School of Biotechnology, Yeungnam University, Gyeongsan, 712-749, Republic of Korea
  1. Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-701, Republic of Korea
  5. Department of Surgery, Seoul National University College of Medicine, Seoul, 110-799, Republic of Korea
  
• ISSN：1573-6776

文摘

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is a transmembrane protein that is structurally similar to CD28. As CTLA-4 has a much higher binding affinity to B7 than CD28, several approaches using soluble CTLA-4 have been tried to down-regulate T cell activity by blocking the interaction between CD28 and B7. We constructed soluble rhesus monkey CTLA-4 immunoglobulin (CTLA-4Ig) containing a critical binding site to B7 combined with a constant Ig heavy chain region in a mammalian system. Flow cytometry analyses indicated that soluble rhesus monkey CTLA-4Ig bound to rhesus monkey CD86 (B7.2). Moreover, soluble rhesus monkey CTLA-4Ig more effectively blocked the rhesus monkey–rhesus monkey allogeneic mixed lymphocyte reaction compared with that of humans. These results indicate that soluble rhesus monkey CTLA-4Ig may be useful in preclinical trials in a rhesus monkey model.