Elementary immunology: Na+ as a regulator of immunity
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- 作者：Valentin Schatz ; Patrick Neubert ; Agnes Schröder ; Katrina Binger…
- 关键词：Local Na+ availability ; Skin salt storage ; Macrophages ; T cells ; Immune cell function and activation
- 刊名：Pediatric Nephrology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：32
- 期：2
- 页码：201-210
- 全文大小：739KB
- 刊物类别：Medicine
- 刊物主题：Pediatrics; Nephrology; Urology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-198X
- 卷排序：32
文摘
The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases with age, inflammation and infection. This increased local Na+ availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na+ availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na+ levels bears broad therapeutic potential: increasing local Na+ availability may help in treating infections, while lowering tissue Na+ levels may be used to treat, for example, autoimmune and cardiovascular diseases.