作者单位:Vimal Patel (1) Nilay Bhatt (2) Pralav Bhatt (3) H. D. Joshi (1)
1. Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India 2. JJT University, Jhunjhunu, Rajasthan, India 3. School of Chemistry, University of KwaZulu-Natal, Westville Campus, Durban, South Africa
ISSN:1554-8120
文摘
Novel compounds of biological interest were synthesized by in situ reduction of Schiff’s base of 5,6-dimethoxy indanone and 1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one in the presence of Ti(OiPr)4 and NaBH3CN. Further alkylation using different alkyl/aryl halides in the presence of NaH in DMF gave a series of novel compounds. A formation of newly synthesized compounds was confirmed on the basis of their spectral and elemental analysis. Further these compounds were screened for their antimicrobial activity and found to have promising antibacterial and antifungal activity.