A convenient and efficient method for the synthesis of new 2-(4-amino substituted benzilidine) indanone derivatives

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• 作者：Reza Teimuri-Mofrad ; Roghaye Nikbakht…
• 关键词：Alzheimer's disease ; Donepezil ; Indanone ; N ; arylation
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：42
• 期：10
• 页码：7501-7511
• 全文大小：799 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675
• 卷排序：42

文摘

An efficient and improved process for the synthesis of novel 1-indanones derivatives has been developed. In the first step of the presented new process, 4-bromobenzaldehyde reacts with 5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-one by N-arylation of corresponding compounds with a variety of aliphatic and aromatic amines to produce a novel category of 1-indanones as the final step. Comparison of this newly designed method with conventional methods show that our method is much more efficient in producing a higher total yield. This innovative synthesis methodology offers several advantages, among which the consumption of inexpensive reagents and the resulting higher total yields of final products are of its remarkable points.