Human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase
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- 作者：Elena Gonzalo-Gil ; María J. Pérez-Lorenzo ; María Galindo…
- 关键词：Arthritis ; Human embryonic stem cell ; derived mesenchymal stromal cells ; T cells ; Cytokines ; Indoleamine 2 ; 3 dioxygenase
- 刊名：Arthritis Research & Therapy
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：18
- 期：1
- 全文大小：3,084 KB
- 刊物主题：Rheumatology; Orthopedics;
- 出版者：BioMed Central
- ISSN：1478-6354
文摘
Background The immunosuppressive and anti-inflammatory properties of mesenchymal stromal cells (MSC) have prompted their therapeutic application in several autoimmune diseases, including rheumatoid arthritis. Adult MSC are finite and their clinical use is restricted by the need for long-term expansion protocols that can lead to genomic instability. Inhibition of Smad2/3 signaling in human pluripotent stem cells (hPSC) provides an infinite source of MSC that match the phenotype and functional properties of adult MSC. Here, we test the therapeutic potential of hPSC-MSC of embryonic origin (embryonic stem cell-derived mesenchymal stromal cells, hESC-MSC) in the experimental model of collagen-induced arthritis (CIA).