Insight into inclusion complexation of indomethacin nicotinamide cocrystals

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• 作者：Hassan Refat H. Ali ; Imran Y. Saleem…
• 关键词：Cocrystals ; β ; Cyclodextrins ; HP ; β ; Cyclodextrin ; Indomethacin ; Inclusion complexation ; Nicotinamide
• 刊名：Journal of Inclusion Phenomena and Macrocyclic Chemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：84
• 期：3-4
• 页码：179-188
• 全文大小：973 KB
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• 作者单位：Hassan Refat H. Ali (1)
  Imran Y. Saleem (2)
  Hesham M. Tawfeek (3)
  
  1. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt
  2. School of Pharmacy and Biomolecular Science, Liverpool John Moores University, Liverpool, UK
  3. Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Organic Chemistry
  Food Science
  Crystallography
  
• 出版者：Springer Netherlands
• ISSN：1573-1111

文摘

The objective of this research was to investigate the feasibility of the interaction between indomethacin-nicotinamide cocrystals with β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the solid-state. The study has emphasized on the possibility of inclusion complex formation and its effect on the dissolution performance of the cocrystals. The solid systems in the molar ratio of 1:1 of the host and guest molecules were prepared by co-grinding and co-evaporation methods and compared with their physical mixtures. Furthermore, the molecular behaviors of the cocrystals in all prepared samples were thoroughly characterized by powder X-ray diffraction, differential scanning calorimetry, Fourier-transform infrared spectroscopy, scanning electron microscopy and in-vitro dissolution performance. The results of these studies indicated that complexes prepared by the co-evaporation method with hydroxypropyl-β-cyclodextrin have shown complete inclusion of the cocrystals into the cyclodextrin cavity and a partial inclusion with β-cyclodextrin. Moreover, a significant (p < 0.05; ANOVA/Tukey) higher in-vitro dissolution was achieved in co-evaporate complex prepared with hydroxypropyl-β-cyclodextrin compared to that prepared with β-cyclodextrin, indomethacin-nicotinamide cocrystals and indomethacin itself.