Monitoring of positron using high-energy gamma camera for proton therapy

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• 作者：Seiichi Yamamoto ; Toshiyuki Toshito ; Masataka Komori…
• 关键词：Proton therapy ; Positron ; Gamma camera ; Imaging
• 刊名：Annals of Nuclear Medicine
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：29
• 期：3
• 页码：268-275
• 全文大小：1,748 KB
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• 刊物主题：Nuclear Medicine; Imaging / Radiology;
• 出版者：Springer Japan
• ISSN：1864-6433

文摘

Purpose In proton therapy, imaging of proton-induced positrons is a useful method to monitor the proton beam distribution after therapy. Usually, a positron emission tomography (PET) system installed in or near the proton beam treatment room is used for this purpose. However, a PET system is sometimes too large and expensive for this purpose. We developed a small field-of-view (FOV) gamma camera for high-energy gamma photons and used it for monitoring the proton-induced positron distribution. Methods The gamma camera used 0.85?mm?×?0.85?mm?×?10?mm Ce:Gd3Al2Ga3O12 (GAGG) pixels arranged in 20?×?20 matrix to form a scintillator block, which was optically coupled to a 1-inch-square position-sensitive photomultiplier tube (PSPMT). The GAGG detector was encased in a 20-mm thick container and a pinhole collimator was mounted on its front. The gamma camera was set 1.2?m from the 35?cm?×?35?cm?×?5?cm plastic phantom in the proton therapy treatment room, and proton beams were irradiated to the phantom with two proton energies. Results The gamma camera had spatial resolution of ~6.7?cm and sensitivity of 3.2?×?10? at 1?m from the collimator surface. For both proton energies, positron distribution in the phantom could be imaged by the gamma camera with 10-min acquisition. The lengths of the range of protons measured from the images were almost identical to the simulation results. Conclusions These results indicate that the developed high-energy gamma camera is useful for imaging positron distributions in proton therapy.