Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis
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- 作者：Zhidan Mei ; Li Zhou ; Youhua Zhu ; Kejia Jie ; Daqing Fan ; Jian Chen…
- 关键词：Interleukin ; 22 ; miR ; 595 ; Sox17 ; Papillary thyroid cancer ; Migration ; Invasion
- 刊名：Tumor Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：37
- 期：9
- 页码：11753-11762
- 全文大小：1,635 KB
- 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
- 卷排序：37
文摘
Interleukin-22 (IL-22) is an inflammatory cytokine mainly produced by activated Th17 and Th22 cells. The data presented here demonstrate that IL-22 induced the migration and invasion of papillary thyroid cancer (PTC) cells. MicroRNA expression analysis and functional studies indicated that IL-22-mediated migration and invasion is positively regulated by miR-595. Further mechanistic studies revealed that sex-determining region Y-box 17 (Sox17) is directly targeted by miR-595. We then demonstrated that IL-22 regulated migration and invasion of PTC cells via inhibiting Sox17 expression. Interestingly, in PTC cell lines and PTC tissues, expression of IL-22 and miR-595 was upregulated and Sox17 downregulated compared with normal thyroid, and their expression levels were closely correlated. Taken together, this present study suggests that IL-22 stimulation enhances the migration and invasion of PTC cells by regulating miR-595 and its target Sox17.