Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes
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- 作者：Siriporn Songsiripradubboon ; Wijit Banlunara ; Polkit Sangvanich…
- 关键词：Acemannan ; Aloe vera ; Biomaterial ; Clinical study ; Histopathological evaluation ; Vital pulp therapy
- 刊名：Odontology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：104
- 期：3
- 页码：329-337
- 全文大小：1,306 KB
- 刊物类别：Medicine
- 刊物主题：Dentistry
- 出版者：Springer Japan
- ISSN：1618-1255
- 卷排序：104
文摘
Acemannan has been previously reported as a direct pulp-capping agent in animal study. This natural material demonstrated its biocompatibility and enhanced reparative dentin formation. The objective of this study was to investigate the action of acemannan as a direct pulp-capping material in human primary teeth with deep caries. Forty-two deeply carious mandibular primary molars from 37 children, aged 7–11 years old diagnosed with reversible pulpitis were studied. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: acemannan or calcium hydroxide. A glass-ionomer cement base was applied to all teeth prior to restoration with stainless steel crowns. Clinical and radiographic evaluation was performed 6 months post-treatment. The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tissue organization. At 6 months, the overall clinical and radiographic success rates of direct pulp capping with acemannan and calcium hydroxide at 6 months were 72.73 and 70.0 %, respectively. The histopathological results indicated that the acemannan-treated group had significantly better histopathological responses compared with the calcium hydroxide-treated group (p < 0.05). These data suggest acemannan offers a valuable alternative biomaterial for vital pulp therapy in primary teeth.