Identification of influenza A nucleoprotein body domain residues essential for viral RNA expression expose antiviral target

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• 作者：Alicia M. Davis ; Jose Ramirez ; Laura L. Newcomb
• 关键词：Influenza ; Virus ; RNA ; Nucleoprotein
• 刊名：Virology Journal
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：2476KB
• 刊物主题：Virology;
• 出版者：BioMed Central
• ISSN：1743-422X
• 卷排序：14

文摘

BackgroundInfluenza A virus is controlled with yearly vaccination while emerging global pandemics are kept at bay with antiviral medications. Unfortunately, influenza A viruses have emerged resistance to approved influenza antivirals. Accordingly, there is an urgent need for novel antivirals to combat emerging influenza A viruses resistant to current treatments. Conserved viral proteins are ideal targets because conserved protein domains are present in most, if not all, influenza subtypes, and are presumed less prone to evolve viable resistant versions. The threat of an antiviral resistant influenza pandemic justifies our study to identify and characterize antiviral targets within influenza proteins that are highly conserved. Influenza A nucleoprotein (NP) is highly conserved and plays essential roles throughout the viral lifecycle, including viral RNA synthesis.