An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model

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• 作者：Yaqian Liu (1)
  Peiyi Song (2)
  Jianwei Liu (3)
  Danny Jian Hang Tng (2)
  Rui Hu (2)
  Hongyan Chen (3)
  Yazhuo Hu (3)
  Cher Heng Tan (4)
  Jianhua Wang (3)
  Jing Liu (3)
  Ling Ye (3)
  Ken-Tye Yong (2)
  
  1. Laboratory Animal Center of the Chinese PLA General Hospital ; Beijing ; 100853 ; People鈥檚 Republic of China
  2. School of Electrical and Electronic Engineering ; Nanyang Technological University ; Singapore ; 639798 ; Singapore
  3. Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics ; Chinese PLA General Hospital ; Beijing ; 100853 ; People鈥檚 Republic of China
  4. Department of Diagnostic Radiology ; Tan Tock Seng Hospital ; 11 Jalan Tan Tock Seng ; Singapore ; 308433 ; Singapore
  
• 关键词：Individualized medicine ; Drug delivery ; Implantable Device ; Biocompatibility ; In Vivo
• 刊名：Biomedical Microdevices
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：17
• 期：1
• 全文大小：3,466 KB
• 参考文献：1. J. Ambati, E.S. Gragoudas, J.W. Miller, T.T. You, K. Miyamoto, F.C. Delori, A.P. Adamis, Transscleral delivery of bioactive protein to the choroid and retina. Invest. Ophthalmol. Vis. Sci. 41(5), 1186鈥?191 (2000)
  2. J. Chen, M. Chu, K. Koulajian, X.Y. Wu, A. Giacca, Y. Sun, A monolithic polymeric microdevice for pH-responsive drug delivery. Biomed. Microdevices 11(6), 1251鈥?257 (2009). doi:10.1007/s10544-009-9344-2 CrossRef
  3. H.D. Chirra, T.A. Desai, Multi-reservoir bioadhesive microdevices for independent rate-controlled delivery of multiple drugs. Small 8(24), 3839鈥?846 (2012). doi:10.1002/smll.201201367 CrossRef
  4. A.J. Chung, Y.S. Huh, D. Erickson, A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release. Biomed. Microdevices 11(4), 861鈥?67 (2009). doi:10.1007/s10544-009-9303-y CrossRef
  5. N.M. Elman, H.L. Ho Duc, M.J. Cima, An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care. Biomed. Microdevices 11(3), 625鈥?31 (2009). doi:10.1007/s10544-008-9272-6 CrossRef
  6. R. Farra, N.F. Sheppard, L. McCabe, R.M. Neer, J.M. Anderson, J.T. Santini, M.J. Cima, R. Langer, First-in-human testing of a wirelessly controlled drug delivery microchip. Sci. Transl. Med. 4, 122ra121 (2012). doi:10.1126/scitranslmed.3003276 CrossRef
  7. H. Gensler, R. Sheybani, P.Y. Li, R. Lo, S. Zhu, K.T. Yong, I. Roy, P.N. Prasad, R. Masood, U.K. Sinha, Implantable MEMS drug delivery device for cancer radiation reduction. In: Micro Electro Mechanical Systems (MEMS), 2010 I.E. 23rd International Conference on (2010) IEEE, pp. 23鈥?6
  8. H. Gensler, R. Sheybani, P.Y. Li, R. Lo Mann, E. Meng, An implantable MEMS micropump system for drug delivery in small animals. Biomed. Microdevices 14(3), 483鈥?96 (2012). doi:10.1007/s10544-011-9625-4 CrossRef
  9. M.M. Gottesman, Mechanisms of cancer drug resistance. Annu. Rev. Med. 53(1), 615鈥?27 (2002) CrossRef
  10. A.C.R. Grayson, I.S. Choi, B.M. Tyler, P.P. Wang, H. Brem, M.J. Cima, R. Langer, Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat. Mater. 2(11), 767鈥?72 (2003). doi:10.1038/nmat998 CrossRef
  11. D.J. Hang Tng, P. Song, R. Hu, C. Yang, K.-T. Yong, High reliability nanosandwiched Pt/Ti multilayer electrode actuators for on-chip biomedical applications. Analyst 139(2), 407鈥?15 (2014). doi:10.1039/c3an01363d CrossRef
  12. S. Hu, S. Zeng, B. Zhang, C. Yang, P. Song, D.J.H. Tng, G. Lin, Y. Wang, T. Anderson, P. Coquet, L. Liu, X. Zhang, K.-T. Yong, Preparation of biofunctionalized quantum dots using microfluidic chips for bioimaging. Analyst (2014). doi:10.1039/c4an00773e
  13. P.L. Huang, P.H. Kuo, Y.J. Huang, H.H. Liao, Y.J.J. Yang, T. Wang, Y.H. Wang, S.S. Lu, A controlled-release drug delivery system on a chip using electrolysis. IEEE Trans. Ind. Electron. 59(3), 1578鈥?587 (2012). doi:10.1109/tie.2011.2160135 CrossRef
  14. D.S. Kohane, R. Langer, Biocompatibility and drug delivery systems. Chem. Sci. 1(4), 441鈥?46 (2010). doi:10.1039/c0sc00203h CrossRef
  15. P. Kurian, B. Kasibhatla, J. Daum, C. Burns, M. Moosa, K. Rosenthal, J. Kennedy, Synthesis, permeability and biocompatibility of tricomponent membranes containing polyethylene glycol, polydimethylsiloxane and polypentamethylcyclopentasiloxane domains. Biomaterials 24(20), 3493鈥?503 (2003) CrossRef
  16. D.A. LaVan, T. McGuire, R. Langer, Small-scale systems for in vivo drug delivery. Nat. Biotechnol. 21(10), 1184鈥?191 (2003). doi:10.1038/nbt876 CrossRef
  17. P.Y. Li, J. Shih, R. Lo, S. Saati, R. Agrawal, M.S. Humayun, Y.C. Tai, E. Meng, An electrochemical intraocular drug delivery device. Sensors and Actuators a-Physical 143(1), 41鈥?8 (2008). doi:10.1016/j.sna.2007.06.034 CrossRef
  18. P.Y. Li, R. Sheybani, J.T.W. Kuo, E. Meng, A parylene bellows electrochemical actuator for intraocular drug delivery. In: Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International, 21鈥?5 June 2009 (2009), pp. 1461鈥?464. doi:10.1109/sensor.2009.5285819
  19. P.Y. Li, R. Sheybani, C.A. Gutierrez, J.T.W. Kuo, E. Meng, A parylene bellows electrochemical actuator. J. Microelectromech. Syst. 19(1), 215鈥?28 (2010). doi:10.1109/jmems.2009.2032670 CrossRef
  20. R. Lin, M.A. Burns, Surface-modified polyolefin microfluidic devices for liquid handling. J. Micromech. Microeng. 15(11), 2156 (2005) CrossRef
  21. R. Lo, P.Y. Li, S. Saati, R. Agrawal, M.S. Humayun, E. Meng, A refillable microfabricated drug delivery device for treatment of ocular diseases. Lab Chip 8(7), 1027鈥?030 (2008). doi:10.1039/b804690e CrossRef
  22. R. Lo, P.-Y. Li, S. Saati, R. Agrawal, M. Humayun, E. Meng, A passive MEMS drug delivery pump for treatment of ocular diseases. Biomed. Microdevices 11(5), 959鈥?70 (2009). doi:10.1007/s10544-009-9313-9 CrossRef
  23. E. Meng, T. Hoang, MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications. Adv. Drug Deliv. Rev. 64(14), 1628鈥?638 (2012). doi:10.1016/j.addr.2012.08.006 CrossRef
  24. A. Mercanzini, K. Cheung, D.L. Buhl, M. Boers, A. Maillard, P. Colin, J.-C. Bensadoun, A. Bertsch, P. Renaud, Demonstration of cortical recording using novel flexible polymer neural probes. Sensors Actuators A Phys. 143(1), 90鈥?6 (2008) CrossRef
  25. R. Padera, E. Bellas, J.Y. Tse, D. Hao, D.S. Kohane, Local Myotoxicity from Sustained Release of Bupivacaine from Microparticles. Anesthesiology 108(5), 921鈥?28 (2008). doi:10.1097/ALN.1090b1013e31816c31818a31848 CrossRef
  26. V.S. Polikov, P.A. Tresco, W.M. Reichert, Response of brain tissue to chronically implanted neural electrodes. J. Neurosci. Methods 148(1), 1鈥?8 (2005) CrossRef
  27. L. Po-Ying, R. Sheybani, C.A. Gutierrez, J.T.W. Kuo, E. Meng, A parylene bellows electrochemical actuator. J. Microelectromech. Syst. 19(1), 215鈥?28 (2010) CrossRef
  28. J.H. Prescott, S. Lipka, S. Baldwin, N.F. Sheppard, J.M. Maloney, J. Coppeta, B. Yomtov, M.A. Staples, J.T. Santini, Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat. Biotechnol. 24(4), 437鈥?38 (2006). doi:10.1038/nbt1199 CrossRef
  29. S. Saati, R. Lo, P.-Y. Li, E. Meng, R. Varma, M.S. Humayun, Mini drug pump for ophthalmic use. Curr. Eye Res. 35(3), 192鈥?01 (2010). doi:10.3109/02713680903521936 CrossRef
  30. J.T. Santini, M.J. Cima, R. Langer, A controlled-release microchip. Nature 397(6717), 335鈥?38 (1999) CrossRef
  31. J.T. Santini, A.C. Richards, R. Scheidt, M.J. Cima, R. Langer, Microchips as controlled drug-delivery devices. Angew. Chem. Int. Ed. 39(14), 2397鈥?407 (2000) CrossRef
  32. R. Sheybani, E. Meng, High-efficiency MEMS electrochemical actuators and electrochemical impedance spectroscopy characterization. J. Microelectromech. Syst. 21(5), 1197鈥?208 (2012). doi:10.1109/jmems.2012.2203103 CrossRef
  33. M. Shobo, H. Yamada, A. Koakutsu, N. Hamada, M. Fujii, K. Harada, K. Ni, N. Matsuoka, Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats. Life Sci. 88(17鈥?8), 761鈥?65 (2011). doi:10.1016/j.lfs.2011.02.014 CrossRef
  34. R.A. Singh, L. Siyuan, N. Satyanarayana, T. Kustandi, S.K. Sinha, Bio-inspired polymeric patterns with enhanced wear durability for microsystem applications. Mater. Sci. Eng. C 31(7), 1577鈥?583 (2011) CrossRef
  35. P. Song, D.J.H. Tng, R. Hu, G. Lin, E. Meng, K.-T. Yong, An electrochemically actuated MEMS device for individualized drug delivery: an in vitro study. Adv. Healthc. Mater. 2(8), 1170鈥?178 (2013). doi:10.1002/adhm.201200356 CrossRef
  36. P. Song, R. Hu, D.J.H. Tng, K.-T. Yong, Moving towards individualized medicine with microfluidics technology. RSC Adv. 4(22), 11499鈥?1511 (2014). doi:10.1039/c3ra45629c CrossRef
  37. K.S. Soppimath, T.M. Aminabhavi, A.R. Kulkarni, W.E. Rudzinski, Biodegradable polymeric nanoparticles as drug delivery devices. J. Control. Release 70(1鈥?), 1鈥?0 (2001). doi:10.1016/s0168-3659(00)00339-4 CrossRef
  38. M. Staples, Microchips and controlled-release drug reservoirs. Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology 2(4), 400鈥?17 (2010). doi:10.1002/wnan.93 CrossRef
  39. M. Staples, K. Daniel, M.J. Cima, R. Langer, Application of micro- and nano-electromechanical devices to drug delivery. Pharm. Res. 23(5), 847鈥?63 (2006). doi:10.1007/s11095-006-9906-4 CrossRef
  40. D. Tng, R. Hu, P. Song, I. Roy, K.-T. Yong, Approaches and challenges of engineering implantable microelectromechanical systems (MEMS) drug delivery systems for in vitro and in vivo applications. Micromachines 3(4), 615鈥?31 (2012) CrossRef
  41. D.J.H. Tng, P. Song, R. Hu, G. Lin, K.-T. Yong, A sustainable approach to individualized disease treatment: The Engineering of a multiple use MEMS drug delivery device. In: Nanoelectronics Conference (INEC), 2013 I.E. 5th International, 2鈥? Jan. 2013 (2013), pp. 153鈥?56. doi:10.1109/inec.2013.6465982
  42. N.C. Tsai, C.Y. Sue, Review of MEMS-based drug delivery and dosing systems. Sensors Actuators A Phys. 134(2), 555鈥?64 (2007). doi:10.1016/j.sna.2006.06.014 CrossRef
  43. X.Q. Yang, B.A. Moosa, L. Deng, L. Zhao, N.M. Khashab, pH-triggered micellar membrane for controlled release microchips. Polym. Chem. 2(11), 2543鈥?547 (2011). doi:10.1039/c1py00300c CrossRef
  44. Y. Zhang, L.Z. Benet, The gut as a barrier to drug absorption. Clin. Pharmacokinet. 40(3), 159鈥?68 (2001) CrossRef
  
• 刊物类别：Engineering
• 刊物主题：Biomedical Engineering
  Biophysics and Biomedical Physics
  Nanotechnology
  Engineering Fluid Dynamics
  
• 出版者：Springer Netherlands
• ISSN：1572-8781

文摘

The use of MEMS implantable drug delivery pump device enables one to program the desired drug delivery profile in the device for individualized medicine treatment to patients. In this study, a MEMS drug delivery device is prepared and employed for in vivo applications. 12 devices are implanted subcutaneously into Kunming mice for evaluating their long term biocompatibility and drug-delivery efficiency in vivo. All the mice survived after device implantation surgery procedures. Histological analysis result reveals a normal wound healing progression within the tissues-to-device contact areas. Serum analysis shows that all measured factors are within normal ranges and do not indicate any adverse responses associated with the implanted device. Phenylephrine formulation is chosen and delivered to the abdominal cavity of the mice by using either the implanted MEMS device (experimental group) or the syringe injection method (control group). Both groups show that they are able to precisely control and manipulate the increment rate of blood pressure in the small animals. Our result strongly suggests that the developed refillable implantable MEMS devices will serve as a viable option for future individualized medicine applications such as glaucoma, HIV-dementia and diabetes therapy.