Current Concepts in the Management of Meconium Aspiration Syndrome

详细信息    查看全文

• 作者：Subhash Chettri ; B. Vishnu Bhat ; B. Adhisivam
• 关键词：Meconium aspiration syndrome ; Endotracheal suction ; Surfactant ; Nitric oxide
• 刊名：The Indian Journal of Pediatrics
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：83
• 期：10
• 页码：1125-1130
• 全文大小：261 KB
• 刊物主题：Pediatrics; Gynecology;
• 出版者：Springer India
• ISSN：0973-7693
• 卷排序：83

文摘

In developing countries, meconium aspiration syndrome (MAS) is an important cause of morbidity and mortality among neonates. The concepts of pathophysiology and management of meconium stained amniotic fluid (MSAF) and meconium aspiration syndrome have undergone tremendous change in recent years. Routine intranatal and postnatal endotracheal suctioning of meconium in vigorous infants is no longer recommended. Recent studies have challenged its role even in non-vigorous infants. Supportive therapy like oxygen supplementation, mechanical ventilation and intravenous fluids are the cornerstone in the management of meconium aspiration syndrome. Availability of surfactant, inhaled nitric oxide, high frequency ventilators and extracorporeal membrane oxygenation has made it possible to salvage more infants with meconium aspiration syndrome. In this review the authors have discussed the current concepts in the pathophysiology and management of MAS. Drugs in trials and future therapeutic targets are also discussed briefly.