Tonic GABA_A Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

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• 作者：S. Schipper ; M. W. Aalbers ; K. Rijkers ; A. Swijsen ; J. M. Rigo…
• 关键词：Extrasynaptic GABAA receptor ; Epilepsy ; Seizures ; Tonic ; Antiepileptic drugs
• 刊名：Molecular Neurobiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：53
• 期：8
• 页码：5252-5265
• 全文大小：723 KB
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182
• 卷排序：53

文摘

Tonic GABA_A receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA_A receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA_A receptors in epilepsy and as potential antiepileptic target will be discussed.