Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037

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• 作者：Emma J. Haagensen ; Huw D. Thomas…
• 关键词：PI3K ; MEK ; Combination ; Synergy ; Colorectal cancer
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：78
• 期：6
• 页码：1269-1281
• 全文大小：1,012 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Pharmacology and Toxicology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0843
• 卷排序：78

文摘

PurposeTumours frequently have defects in multiple oncogenic pathways, e.g. MAPK and PI3K signalling pathways, and combinations of targeted therapies may be required for optimal activity. This study evaluated the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037, as single agents and in combination, in colorectal carcinoma cell lines and tumour xenograft-bearing mice.