A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes
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- 作者：Thomas Jax ; Alin Stirban ; Arne Terjung ; Habib Esmaeili…
- 关键词：Type 2 diabetes ; Dipeptidyl peptidase ; 4 inhibitor ; Linagliptin ; Sulphonylurea ; Endothelial function ; Macrovascular ; Microvascular ; Flow ; mediated vasodilation
- 刊名：Cardiovascular Diabetology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1354KB
- 刊物主题：Diabetes; Angiology; Cardiology;
- 出版者：BioMed Central
- ISSN：1475-2840
- 卷排序：16
文摘
BackgroundStudies of dipeptidyl peptidase (DPP)-4 inhibitors report heterogeneous effects on endothelial function in patients with type 2 diabetes (T2D). This study assessed the effects of the DPP-4 inhibitor linagliptin versus the sulphonylurea glimepiride and placebo on measures of macro- and microvascular endothelial function in patients with T2D who represented a primary cardiovascular disease prevention population.