Hypoxyprobe™ reveals dynamic spatial and temporal changes in hypoxia in a mouse model of endometrial breakdown and repair

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• 作者：Fiona L. Cousins ; Alison A. Murray ; Jessica P. Scanlon…
• 关键词：Endometrium ; Hypoxia ; Menstruation ; Repair ; Angiogenesis
• 刊名：BMC Research Notes
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：1
• 全文大小：1,573 KB
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• 作者单位：Fiona L. Cousins (1)
  Alison A. Murray (2)
  Jessica P. Scanlon (1)
  Philippa T. K. Saunders (1)
  
  1. Medical Research Council Centre for Inflammation Research, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
  2. Medical Research Council Centre for Reproductive Health, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1756-0500

文摘

Background Menstruation is the culmination of a cascade of events, triggered by the withdrawal of progesterone at the end of the menstrual cycle. Initiation of tissue destruction and endometrial shedding causes spiral arteriole constriction in the functional layer of the endometrium. Upregulation of genes involved in angiogenesis and immune cell recruitment, two processes that are essential to successful repair and remodelling of the endometrium, both thought to be induced by reduced oxygen has been reported. Evidence for stabilisation/increased expression of the transcriptional regulator hypoxia inducible factor in the human endometrium at menses has been published. The current literature debates whether hypoxia plays an essential role during menstrual repair, therefore this study aims to delineate a role for hypoxia using a sensitive detection method (the Hypoxyprobe™) in combination with an established mouse model of endometrial breakdown and repair.