Neuroprotective effect of Shenfu Injection ( following cardiac arrest in pig correlates with improved mitochondrial function and cerebral glucose uptake

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• 作者：Yi Zhang (1)
  Chun-sheng Li (2)
  Cai-jun Wu (2)
  Jun Yang (2)
  Chen-chen Hang (2)
  
• 关键词：cardiopulmonary resuscitation ; Shenfu Injection ; positron emission tomography/computed tomography ; mitochondrial membrane potential ; mitochondrial respiratory property ; Chinese medicine
• 刊名：Chinese Journal of Integrative Medicine
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：20
• 期：11
• 页码：835-843
• 全文大小：757 KB
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• 作者单位：Yi Zhang (1)
  Chun-sheng Li (2)
  Cai-jun Wu (2)
  Jun Yang (2)
  Chen-chen Hang (2)
  
  1. Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China
  2. Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China
  
• ISSN：1993-0402

文摘

Objective To test whether Shenfu Injection ( SFI) might attenuate the impact of cerebral energy dysfunction after resuscitation in a pig model of cardiac arrest (CA). Methods Thirty-four Wuzhishan miniature inbred pigs were randomly divided into three groups: the SFI group (n=12), the saline group (SA group, n=12), and the sham-operated group (sham group, n=10). Following successful return of spontaneous circulation (ROSC) from 8-min untreated ventricular fibrillation, animals received a continuous infusion of either SFI (0.2 mL/min) or saline for 6 h. Cerebral performance category score was evaluated at 24 and 48 h after ROSC, followed by positron emission tomography and computed tomography scans of cerebral glucose uptake. Surviving pigs were euthanized 48 h after ROSC, and the brains were removed for detecting mitochondrial function. Results Compared with the SA group, SFI treatment produced a better neurologic outcome 48 h after ROSC (PP>0.05). After ROSC, the SA group showed a decrease in the maximum standardized uptake value of different regions in the brain tissue, where SFI treatment can ameliorate these decreases (PPPP Conclusion SFI treatment after resuscitation has significant neuroprotective effects against disruption of cerebral energy metabolism from CA by improving glucose uptake and by normalizing mitochondrial function.