Cold stress aggravates inflammatory responses in an LPS-induced mouse model of acute lung injury

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• 作者：Su-Yeon Joo ; Mi-Ju Park ; Kyun-Ha Kim…
• 刊名：International Journal of Biometeorology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：60
• 期：8
• 页码：1217-1225
• 全文大小：2,096 KB
• 刊物类别：Earth and Environmental Science
• 刊物主题：Life Sciences
  Animal Physiology
  Plant Physiology
  Environmental Medicine/Environmental Psychology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1254
• 卷排序：60

文摘

Although the relationship between environmental cold temperature and susceptibility to respiratory infection is generally accepted, the effect of ambient cold temperature on host reactivity in lung inflammation has not been fully studied. To examine the function of ambient cold temperature on lung inflammation, mice were exposed to 4 °C for 8 h each day for 14 days. In the lungs of mice exposed to cold stress, inflammatory cells in bronchoalveolar lavage (BAL) fluid and lung tissues were slightly increased by about twofold. However, the structures of pulmonary epithelial cells were kept within normal limits. Next, we examined the effect of cold stress on the inflammatory responses in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. The infiltration of neutrophils and inflammation of lung tissue determined by histology were significantly increased by exposure to ambient cold temperature. In addition, the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-17, and monokine induced by gamma interferon (MIG) was elevated by exposure to cold stress. Therefore, we suggest that cold stress is a factor that exacerbates lung inflammation including ALI. To our knowledge, this is the first report on the relationship between cold stress and severity of lung inflammation.KeywordsCold stressInflammationAcute lung injuryLipopolysaccharideNeutrophil