DISC1 Ser704Cys impacts thalamic-prefrontal connectivity

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• 作者：Bing Liu (1) (2)
  Lingzhong Fan (1)
  Yue Cui (1) (2)
  Xiaolong Zhang (1)
  Bing Hou (1) (2)
  Yonghui Li (3)
  Wen Qin (4)
  Dawei Wang (4)
  Chunshui Yu (4)
  Tianzi Jiang (1) (2) (3) (5)
  
  1. Brainnetome Center ; Institute of Automation ; Chinese Academy of Sciences ; Beijing ; 100190 ; China
  2. National Laboratory of Pattern Recognition ; Institute of Automation ; Chinese Academy of Sciences ; Beijing ; 100190 ; China
  3. Queensland Brain Institute ; The University of Queensland ; Brisbane ; QLD ; 4072 ; Australia
  4. Department of Radiology ; Tianjin Medical University General Hospital ; No. 154 ; Anshan Road ; Heping District ; Tianjin ; 300052 ; China
  5. Key Laboratory for NeuroInformation of Ministry of Education ; School of Life Science and Technology ; University of Electronic Science and Technology of China ; Chengdu ; 610054 ; China
  
• 关键词：DISC1 ; Functional connectivity density ; Anatomical connectivity ; Thalamus ; Thalamic ; prefrontal circuit
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：220
• 期：1
• 页码：91-100
• 全文大小：748 KB
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• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders.