Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population

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• 作者：Huan Chen (1)
  Junquan Xu (2) (3)
  Yuxi Zhou (2) (3)
  Yong Gao (2) (3)
  Guoqing Wang (2) (3)
  Jiguang Xia (2) (3)
  Michael SY Huen (4)
  Wai Ting Siok (5) (6)
  Yuyang Jiang (7)
  Li Hai Tan (8) (9)
  Yimin Sun (10) (2) (3) (7)
  
  1. State Key Laboratory of Proteomics ; Beijing Proteome Research Center ; Beijing Institute of Radiation Medicine ; Beijing ; 102206 ; China
  2. National Engineering Research Center for Beijing Biochip Technology ; Beijing ; 102206 ; China
  3. CapitalBio Corporation ; Beijing ; 102206 ; China
  4. Department of Anatomy ; The University of Hong Kong ; Hong Kong ; China
  5. State Key Laboratory of Brain and Cognitive Sciences ; The University of Hong Kong ; Hong Kong ; China
  6. School of Humanities ; The University of Hong Kong ; Hong Kong ; China
  7. The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology ; The Graduate School at Shenzhen ; Tsinghua University ; Shenzhen ; China
  8. Neuroimaging Laboratory ; Department of Biomedical Engineering ; School of Medicine ; Shenzhen University ; Shenzhen ; China
  9. Guangdong Key Laboratory of Biomedical Information Detection and Ultrasound Imaging ; Shenzhen ; 518060 ; China
  10. Medical Systems Biology Research Center ; Department of Biomedical Engineering ; Tsinghua University School of Medicine ; Beijing ; China
  
• 关键词：Developmental dyslexia ; GNPTAB ; GNPTG ; NAGPA ; SNPs
• 刊名：BMC Genetics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：705 KB
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• 刊物主题：Life Sciences, general; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics; Genetics and Population Dynamics;
• 出版者：BioMed Central
• ISSN：1471-2156

文摘

Background Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis. Results The study was carried out in an unrelated Chinese cohort with 502 dyslexic individuals and 522 healthy controls. In all, 21 Tag SNPs covering GNPTAB, GNPTG and NAGPA were subjected to genotyping. Association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB and rs882294 in NAGPA with developmental dyslexia was identified after FDR correction for multiple comparisons. Conclusion Our results revealed that the stuttering risk genes GNPTAB and NAGPA might also associate with developmental dyslexia in the Chinese population.