Radiotracer methods and neutron activation analysis for the investigation of nanoparticle biokinetics in living organisms

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• 作者：A. A. Antsiferova (1)
  Yu. P. Buzulukov (1)
  V. A. Demin (1) (2)
  V. F. Demin (1)
  D. A. Rogatkin (3)
  E. N. Petritskaya (3)
  L. F. Abaeva (3)
  P. K. Kashkarov (1) (2) (4)
  
  1. National Research Centre 鈥淜urchatov Institute鈥? pl. Kurchatov 1 ; Moscow ; 123182 ; Russia
  2. Moscow Institute of Physics and Technology ; State University ; Institutskii per. 9 ; Dolgoprudnyi ; Moscow oblast ; 141700 ; Russia
  3. Vladimirsky Regional Research and Clinical Institute (MONIKI) ; ul. Shchepkina 61/2 ; Moscow ; 129110 ; Russia
  4. Moscow State University ; Moscow ; 119991 ; Russia
  
• 刊名：Nanotechnologies in Russia
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：10
• 期：1-2
• 页码：100-108
• 全文大小：282 KB
• 参考文献：1. Project on Emerging Nanotechnologies (Woodrow Wilson International Centre for Scholar, Washington). http://www.nanotechproject.org
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nanotechnology
  Industrial and Production Engineering
  Manufacturing, Machines and Tools
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1995-0799

文摘

The physical foundations and methodological issues of nuclear activation methods (radiotracers and neutron activation analysis) have been discussed in regards to a study of assimilation of a number of inorganic nanoparticles (NPs) by living organisms and their distribution in organs and excretion. The methods of activation of NPs within a colloidal solution or biological samples have been analyzed. Advantages of the radioactive tracer method and neutron activation analysis have been compared. A brief overview of a number of successful works using nuclear methods for studying the interaction of silver, gold, selenium, and zinc and titanium oxide NPs with living organisms has been given. As an example, a description and results of the experiment on long-term (28 days) injection of silver NPs into laboratory mice have been given. The abilities of neutron activation analysis to estimate the mass of residual blood (and the NPs in it) in biological samples and to confirm the penetration of the NPs through the blood-brain barrier in quantitative terms have been demonstrated.